in methanol T=25 - 60°C; 11 h;

ethanol

in methanol 2 h; Heating;

hydrogen cyanide; water

water

1: 60 percent / methanol / 24 h / Heating 2: 70 percent / lithium aluminium hydride / tetrahydrofuran / 72 h / Heating 3: 59 percent / formic acid / 10 h / Heating View Scheme

1: 60 percent / methanol / 24 h / Heating 2: 70 percent / lithium aluminium hydride / tetrahydrofuran / 72 h / Heating 3: 59 percent / formic acid / 10 h / Heating 4: 25 percent / benzene / 48 h / Heating 5: 66.6 percent / 6N HCl / 48 h / Heating View Scheme

2-(2,4,6-trimethyl-phenyl)-2,5,6,7-tetrahydro-pyrrolo[2,1-c] [1,2,4]triazol-4-ylium perchlorate; (4aR,9aS)-6-bromo-4-hydroxy-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one; potassium carbonate in isopropanol acetate T=23°C; 24 h;

2-(2,4,6-trimethyl-phenyl)-2,5,6,7-tetrahydro-pyrrolo[2,1-c] [1,2,4]triazol-4-ylium perchlorate; (4aR,9aS)-6-bromo-4-hydroxy-4,4a,9,9a-tetrahydroindeno[2,1-b][1,4]oxazin-3(2H)-one; potassium carbonate in isopropanol acetate T=23°C; 24 h; Resolution of racemate;

1: 60 percent / methanol / 24 h / Heating 2: 70 percent / lithium aluminium hydride / tetrahydrofuran / 72 h / Heating 3: 67 percent / triethylamine / benzene / Heating 4: 70 percent / hydrogen / 10percent Pd-C / acetic acid / 12 h / 1838.8 Torr 5: 63 percent / triethylamine / acetone / Ambient temperature 6: 61 percent / dil. HCl / 24 h / Heating View Scheme