2-甲基-3-硝基苯乙腈合成路线 （共 20 条）
反应条件
in ethanol; water T=90°C; 4 h;
参考文献
CALITHERA BIOSCIENCES INC.; LI, Jim; CHEN, Lijing; GOYAL, Bindu; LAIDIG, Guy; STANTON, Timothy, Friend; SJOGREN, Eric, Brian
Patent: WO2013/78123 A1, 2013 ;
Location in patent: Page/Page column 122 ;
WO 2013/078123 A1
反应条件
in DMF (N,N-dimethyl-formamide) T=20°C; 72 h;
参考文献
Pfizer Inc
Patent: US2005/267096 A1, 2005 ;
Location in patent: Page/Page column 29 ;
US 20050267096 A1
反应条件
sodium iodide in N,N-dimethyl-formamide
参考文献
US5952362 A1, ;
US 5952362 A
参考文献
Gallagher, Gregory; Lavanchy, Patricia G.; Wilson, James W.; Hieble, J. Paul; DeMarinis, Robert M.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1533 - 1536
反应条件
1: SOCl2 2: NaBH4 / tetrahydrofuran 3: SOCl2, pyridine View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 30, # 12 p. 973 - 982
反应条件
1: SOCl2, pyridine View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 30, # 12 p. 973 - 982
反应条件
in acetonitrile Heating / reflux; Product distribution / selectivity;
参考文献
WO2006/123356 A1, ;
Page/Page column 22 ;
反应条件
1: NaBH4 / tetrahydrofuran 2: SOCl2, pyridine View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 30, # 12 p. 973 - 982
反应条件
1: H2SO4, CrO3 2: H2SO4 3: NaBH4 4: (i) PBr3, (ii) /BRN= 4652394/ View Scheme
参考文献
Journal of the Chemical Society. Perkin transactions 1, , vol. 14, p. 1935 - 1939
反应条件
1: NaBH4 2: (i) PBr3, (ii) /BRN= 4652394/ View Scheme
参考文献
Journal of the Chemical Society. Perkin transactions 1, , vol. 14, p. 1935 - 1939
