N,N-二环己脲合成路线

13726-67-5Boc-L-天冬氨酸+32213-95-9L-天冬氨酸二甲酯盐酸盐+121-44-8三乙胺→554-68-7三乙胺盐酸盐+2387-23-7N,N-二环己脲+167082-77-1

参考文献

Deutsches Krebsforschungszentrum Stiftung des oeffentlichen Rechts
Patent: EP1647283 A1, 2006 ;
Location in patent: Page/Page column 5-6 ;

6066-82-6N-羟基丁二酰亚胺+156-38-7对羟基苯乙酸+538-75-0二环己基碳二亚胺→73158-83-5+2387-23-7N,N-二环己脲

参考文献

Obschestvo S Ogranichennoi Otvetstennostiyu "Pharmenterprises"
Patent: EP1876169 A1, 2008 ;
Location in patent: Page/Page column 19 ;

305847-08-9+2921-20-2十四烷基硫代乙酸+538-75-0二环己基碳二亚胺→

参考文献

Darteil, Raphael; Caumont-Bertrand, Kanne; Najib, Jamila
Patent: US2006/252827 A1, 2006 ;
Location in patent: Page/Page column 17 ;

29427-69-83-羰基-1-茚酸+112217-71-7+538-75-0二环己基碳二亚胺→921213-08-3+2387-23-7N,N-二环己脲

参考文献

China Pharmaceutical University; Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Yangtze River Pharmaceutical Group Co., Ltd.
Patent: EP2045243 A1, 2009 ;
Location in patent: Page/Page column 8-9 ;
EP 2045243 A1

896121-49-6+115061-55-7+538-75-0二环己基碳二亚胺→

参考文献

MARS, INCORPORATED
Patent: WO2007/2877 A1, 2007 ;
Location in patent: Page/Page column 27 ;

134469-06-0+538-75-0二环己基碳二亚胺+210366-17-9→770738-07-3+2387-23-7N,N-二环己脲

参考文献

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Patent: WO2008/8797 A2, 2008 ;
Location in patent: Page/Page column 59 ;

733010-31-6+57-10-3棕榈酸+538-75-0二环己基碳二亚胺→

参考文献

Darteil, Raphael; Caumont-Bertrand, Karine; Najib, Jamila
Patent: US2006/69156 A1, 2006 ;
Location in patent: Page/Page column 21 ;
US 20060069156 A1

2038-03-1N-(2-氨基乙基)吗啉+944159-19-7+38194-50-2舒林酸→944159-16-4+2387-23-7N,N-二环己脲

参考文献

SOUTHERN RESEARCH INSTITUTE
Patent: WO2007/81694 A2, 2007 ;
Location in patent: Page/Page column 10; 12-13 ;

934333-69-4→

参考文献

TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH
Patent: EP1935892 A1, 2008 ;
Location in patent: Page/Page column 11-12 ;

1122-56-1环己甲酰胺→2387-23-7N,N-二环己脲

参考文献

Liu, Peng; Wang, Zhiming; Hu, Xianming
European Journal of Organic Chemistry, 2012 , # 10 p. 1994 - 2000