4-氟-3-三氟甲基苯胺合成路线 （共 17 条）
反应条件
iron; ammonium chloride
参考文献
Journal of Medicinal Chemistry, , vol. 7, p. 572 - 573
反应条件
bismuth; hydrogen fluoride in dichloromethane Yield given;
参考文献
Tordeux, Marc; Wakselman, Claude
Journal of Fluorine Chemistry, 1995 , vol. 74, # 2 p. 251 - 254
反应条件
1: With hydrogenchloride; acetic acid; sodium nitrite in water T=0°C; 1 h; 2: With hydrogenchloride; tin(ll) chloride in water 0.5 h; 3: in water pH=12; Alkaline conditions;
参考文献
Reiter, Lawrence A.; Linde, Robert G.
Patent: US2008/76771 A1, 2008 ;
Location in patent: Page/Page column 31 ;
反应条件
tert.-butylnitrite; copper(ll) bromide in acetonitrile T=20°C; Cooling with iceInert atmosphere;
参考文献
GLAXO GROUP LIMITED; DENG, Guanghui; LIN, Xichen; REN, Feng; ZHAO, Baowei
Patent: WO2011/134280 A1, 2011 ;
Location in patent: Page/Page column 52 ;
WO 2011/134280 A1
反应条件
1: 116 g / Et3N / CHCl3 / 48 h 2: 87 percent / fuming HNO3 / 0.5 h / 0 °C View Scheme
参考文献
Ohmori; Sakamoto; Kubota; Shimizu-Sasamata; Okada; Kawasaki; Hidaka; Togami; Furuya; Murase
Journal of Medicinal Chemistry, 1994 , vol. 37, # 4 p. 467 - 475
参考文献
Finger,G.C. et al.
Journal of Medicinal Chemistry, 1964 , vol. 7, p. 572 - 573
参考文献
Finger,G.C. et al.
Journal of Medicinal Chemistry, 1964 , vol. 7, p. 572 - 573
参考文献
The State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University; The University of Oregon; The Regents of the University of California
Patent: US5514680 A1, 1996 ;
US 5514680 A
反应条件
triethylamine in chloroform Ambient temperature;
参考文献
Ohmori; Sakamoto; Kubota; Shimizu-Sasamata; Okada; Kawasaki; Hidaka; Togami; Furuya; Murase
Journal of Medicinal Chemistry, 1994 , vol. 37, # 4 p. 467 - 475
反应条件
sulfuric acid; urea; sodium nitrite in water; toluene
参考文献
Ube Industries, Ltd.
Patent: US5892126 A1, 1999 ;
