2-氟-2-磷酰基乙酸三乙酯合成路线 （共 33 条）
反应条件
n-butyllithium in tetrahydrofuran; hexane 1.) -78 deg C, 2.) -78 deg C, 1 h; r.t., 16 h;
参考文献
Thenappan, Alagappan; Burton, Donald J.
Journal of Fluorine Chemistry, 1996 , vol. 77, # 1 p. 45 - 50
反应条件
(i) NaH, Et2O, (ii) /BRN= 1740180/; Multistep reaction;
参考文献
Machleidt,H.; Wessendorf,R.
Justus Liebigs Annalen der Chemie, 1964 , vol. 674, p. 1 - 10
反应条件
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Thenappan, Alagappan; Burton, Donald J.
Tetrahedron Letters, 1989 , vol. 30, # 41 p. 5571 - 5574
参考文献
Song, Yonghong; Clizbe, Lane; Bhakta, Chhaya; Teng, Willy; Li, Wenhao; Wong, Paul; Huang, Brian; Sinha, Uma; Park, Gary; Reed, Andrea; Scarborough, Robert M; Zhu, Bing-Yan
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 15 p. 2043 - 2046
反应条件
1: With n-butyllithium in tetrahydrofuran T=-78°C; Wittig-Horner Reaction; 2: With bromine in tetrachloromethane 3: With sodium hydroxide in ethanol; water
参考文献
Eddarir, Said; Kajjout, Mohammed; Rolando, Christian
Tetrahedron, 2013 , vol. 69, # 6 p. 1735 - 1738
反应条件
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Thenappan, Alagappan; Burton, Donald J.
Journal of Organic Chemistry, 1990 , vol. 55, # 15 p. 4639 - 4642
反应条件
sodium hydroxide in water T=20°C; 20 h;
参考文献
Sano, Shigeki; Teranishi, Rie; Nagao, Yoshimitsu
Tetrahedron Letters, 2002 , vol. 43, # 50 p. 9183 - 9186
反应条件
diisopropylamine in tetrahydrofuran; hexane; water
参考文献
The Wellcome Foundation Limited
Patent: US5116862 A1, 1992 ;
反应条件
1: (diethoxy-phosphoryl)-fluoro-acetic acid ethyl ester With n-butyllithium in tetrahydrofuran; hexane T=0°C; 1 h; 2: pivalaldehyde in tetrahydrofuran; hexane T=0 - 20°C; Horner-Wadsworth-Emmons reaction; Title compound not separated from byproducts;
参考文献
Sano, Shigeki; Kuroda, Yoko; Saito, Katsuyuki; Ose, Yukiko; Nagao, Yoshimitsu
Tetrahedron, 2006 , vol. 62, # 51 p. 11881 - 11890
反应条件
1: (diethoxy-phosphoryl)-fluoro-acetic acid ethyl ester With sodium hydride in diethyl ether T=-5°C; 0.0833333 h; 2: cyclopentanone With Wadsworth-Horner-Emmons reagent in diethyl ether 4 h;
参考文献
Van Der Veken, Pieter; Senten, Kristel; Kertesz, Istvan; De Meester, Ingrid; Lambeir, Anne-Marie; Maes, Marie-Berthe; Scharpe, Simon; Haemers, Achiel; Augustyns, Koen
Journal of Medicinal Chemistry, 2005 , vol. 48, # 6 p. 1768 - 1780
