2-氟-2-磷酰基乙酸三乙酯合成路线 （共 33 条）
反应条件
Michaelis-Arbuzov reaction; 0.0333333 h; microwave irradiation;
参考文献
Kiddle, James J.; Gurley, Alison F.
Phosphorus, Sulfur and Silicon and Related Elements, 2000 , vol. 160, p. 195 - 205
反应条件
sodium hexamethyldisilazane; N-Fluoro-o-benzenedisulfonimide in tetrahydrofuran 1.) -78 deg C, 10 min; -78 to 0 deg C, 0.5 h, 2.) 0 deg C, 2 h;
参考文献
Davis, Franklin A.; Han, Wei; Murphy, Christopher K.
Journal of Organic Chemistry, 1995 , vol. 60, # 15 p. 4730 - 4737
反应条件
sodium hydride; fluorine in acetonitrile T=5°C; 1.) 1 h, 2.) 4 h;
参考文献
Journal of Fluorine Chemistry, , vol. 92, # 1 p. 45 - 52
反应条件
in tetrahydrofuran Substitution;
参考文献
Zhang, Xin; Weiming, Qiu; Burton, Donald J.
Tetrahedron Letters, 1999 , vol. 40, # 14 p. 2681 - 2684
反应条件
Condensation; P=30.0024 Torr; 19 h; Heating;
参考文献
Kvicala, Jaroslav; Vlasakova, Ruzena; Plocar, Jakub; Paleta, Oldrich; Pelter, Andrew
Collection of Czechoslovak Chemical Communications, 2000 , vol. 65, # 5 p. 772 - 788
反应条件
1: 1.) n-BuLi / 1.) hexane, THF, -78 deg C, 2.) hexane, THF, -78 deg C to -40 deg C 2: ethanol, 2 N HCl, water / hexane; tetrahydrofuran; CH2Cl2 / -40 °C View Scheme
参考文献
Synthetic Communications, , vol. 24, # 9 p. 1317 - 1322
反应条件
perchloryl fluoride in ethanol
参考文献
Justus Liebigs Annalen der Chemie, , vol. 693, p. 134 - 157
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 7, p. 241 - 243
Zhurnal Organicheskoi Khimii, , vol. 7, p. 249 - 251
反应条件
n-butyllithium; chloro-trimethyl-silane; ethanol 1.) 1.) THF, hexane, -78 deg C, 5 min, 2.) THF, -78 deg C, 30 min, 3.) -78 deg C to 0 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Tetrahedron, , vol. 53, # 18 p. 6391 - 6400
