1-甲基-5-(三氟甲基)-1H-吡唑-4-羧酸乙酯合成路线 （共 4 条）
反应条件
1: methylhydrazine With hydrogenchloride in ethanol T=0°C; 0.5 h; 2: ethyl 2-ethoxymethylidene-3-oxo-3-trifluoromethylpropionate in ethanol T=0°C; 18 h; 3: With sodium carbonate in ethanol; water
参考文献
PFIZER JAPAN INC.; PFIZER INC.; RENOVIS, INC.
Patent: WO2008/59370 A2, 2008 ;
Location in patent: Page/Page column 52 ;
WO 2008/059370 A2
反应条件
sodium hydroxide in water; toluene
反应条件
in 1,2-dichloro-benzene T=180°C; 24 h; Sealed tube; Overall yield = 94 percent; Overall yield = 104 mg; regioselective reaction;
参考文献
Journal of Organic Chemistry, , vol. 78, # 8 p. 4049 - 4064
