sodium hydrogencarbonate; Zinc chloride in n-heptane; water; toluene

zinc(II) chloride in n-heptane; benzene 211 h; Heating;

zinc(II) chloride in n-heptane; toluene 60 h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

ethanol

potassium tert-butylate; tert-butyl alcohol

Reaktion ueber mehrere Stufen;

1: 1.) CH(OEt)3; 2.) TsOH*H2O / 1.) H2SO4, 12 deg C, 1440 min; 2.) Et2O, H2O, 5 min, r.t. 2: LiAlH4 / various solvent(s) / 2.5 h / 55 °C View Scheme

暂无反应条件数据

potassium carbonate

1: 1.) CH(OEt)3; 2.) TsOH*H2O / 1.) H2SO4, 12 deg C, 1440 min; 2.) Et2O, H2O, 5 min, r.t. 2: LiAlH4 / various solvent(s) / 2.5 h / 55 °C 3: 93 percent / Ti(i-PrO), t-BuOOH / CH2Cl2; 2,2,4-trimethyl-pentane / -67 °C 4: 91 percent / pyridine / 4 h / 0 °C 5: 87 percent / MgSO4, H2O, montmorillonite / toluene / 0.05 h 7: oxalyl chloride, (i-Pr)2EtN, DMSO / CH2Cl2 / 4 h 8: t-BuOK / tetrahydrofuran / 4 h / Ambient temperature 9: 94 percent / DIBAH, H2O, MeOH / diethyl ether; hexane / 1 h / Ambient temperature 10: 91 percent / MnO2 / ethyl acetate / 2.5 h / Ambient temperature 11: 70 percent / 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidone, BuLi / tetrahydrofuran; hexane / 2 h / Ambient temperature 12: 75 percent / H2 / Lindlar-catalyst / ethyl acetate / 0.5 h View Scheme