2-溴-5-甲基-3-硝基吡啶合成路线 （共 4 条）
反应条件
phosphorus oxytribromide in N,N-dimethyl-formamide T=0 - 80°C; 12 h;
参考文献
WO2009/9740 A1, ;
Page/Page column 52 ;
WO 2009/009740 A1
反应条件
1: With hydrogen bromide in water T=-10 - 0°C; 2: With bromine; sodium nitrite in water T=-10 - 0°C; 1 h; 3: With sodium hydroxide in water T=0 - 20°C; 1 h;
参考文献
WO2006/76644 A2, ;
Page/Page column 204-205 ;
WO 2006/076644 A2
反应条件
1: With iron; acetic acid T=80°C; 0.5 h; 2: With sodium hydrogencarbonate in water
参考文献
WO2006/76644 A2, ;
Page/Page column 205 ;
WO 2006/076644 A2
反应条件
in N,N-dimethyl-formamide T=70°C; 1.5 h;
参考文献
CHEMOCENTRYX, INC.
Patent: WO2009/9740 A1, 2009 ;
Location in patent: Page/Page column 52 ;
WO 2009/009740 A1
