4,4-二甲基-2-咪唑并啉合成路线 （共 15 条）
参考文献
Betschart; Hegedus
Journal of the American Chemical Society, 1992 , vol. 114, # 13 p. 5010 - 5017
反应条件
1: 1,3-diaza-1-propene With n-butyllithium in tetrahydrofuran; hexane T=-78 - 20°C; 2: 3-bromo-2-methylprop-1-ene in tetrahydrofuran; hexane T=-78 - 50°C;
参考文献
Kuhn, Kevin M.; Bourg, Jean-Baptiste; Chung, Cheol K.; Virgil, Scott C.; Grubbs, Robert H.
Journal of the American Chemical Society, 2009 , vol. 131, p. 5313 - 5320
参考文献
Puntener; Hellman; Kuester; Hegedus
Journal of Organic Chemistry, 2000 , vol. 65, # 24 p. 8301 - 8306
反应条件
1 h, RT, then 150 deg C, 1 h, and 220 deg C, 30 min;
参考文献
Bieraeugel, H.; Plemp, R.; Hiemstra, H. C.; Pandit, U. K.
Tetrahedron, 1983 , vol. 39, # 23 p. 3971 - 3980
反应条件
sodium hydroxide in methanol; water 4 h; Heating; Yield given;
参考文献
Jung, Sang-Hun; Kohn, Harold
Tetrahedron Letters, 1984 , vol. 25, # 4 p. 399 - 402
反应条件
triethylamine in dichloromethane
0 deg C, then warming to RT;
参考文献
Bieraeugel, H.; Plemp, R.; Hiemstra, H. C.; Pandit, U. K.
Tetrahedron, 1983 , vol. 39, # 23 p. 3971 - 3980
反应条件
triethylamine in dichloromethane
0 deg C, then warming to RT, 1 h;
参考文献
Bieraeugel, H.; Plemp, R.; Hiemstra, H. C.; Pandit, U. K.
Tetrahedron, 1983 , vol. 39, # 23 p. 3971 - 3980
反应条件
1: 62 percent / triethylamin / CH2Cl2 / 0 deg C, then warming to RT
2: 80 percent / CH2Cl2 / 6 h / Heating
View Scheme
参考文献
Bieraeugel, H.; Plemp, R.; Hiemstra, H. C.; Pandit, U. K.
Tetrahedron, 1983 , vol. 39, # 23 p. 3971 - 3980
反应条件
1: 94 percent / triethylamine / CH2Cl2 / 0 deg C, then warming to RT, 1 h
2: 76 percent / CH2Cl2 / Heating
View Scheme
参考文献
Bieraeugel, H.; Plemp, R.; Hiemstra, H. C.; Pandit, U. K.
Tetrahedron, 1983 , vol. 39, # 23 p. 3971 - 3980
反应条件
1: 62 percent / triethylamin / CH2Cl2 / 0 deg C, then warming to RT
2: 80 percent / CH2Cl2 / 6 h / Heating
3: 91 percent / NaBH4 / ethanol / 1 h / 0 °C
View Scheme
参考文献
Bieraeugel, H.; Plemp, R.; Hiemstra, H. C.; Pandit, U. K.
Tetrahedron, 1983 , vol. 39, # 23 p. 3971 - 3980
