2-氨基-4-甲基苯甲酸合成路线 （共 49 条）
反应条件
in tetrahydrofuran T=20°C;
参考文献
Miller, J. Richard; Thanabal, Venkataraman; Melnick, Michael M.; Lall, Manjinder; Donovan, Charles; Sarver, Ronald W.; Lee, Doh-Yeel; Ohren, Jeff; Emerson, Don
Chemical Biology and Drug Design, 2010 , vol. 75, # 5 p. 444 - 454
参考文献
Mitscher; Gracey; Clark III Suzuki
Journal of Medicinal Chemistry, 1978 , vol. 21, # 5 p. 485 - 489
参考文献
Niementowski; Rozanski
Chemische Berichte, 1889 , vol. 22, p. 1673,1674
参考文献
Moszew; Zankowska-Jasinska
Roczniki Chemii, 1958 , vol. 32, p. 235,238
Chem.Abstr., 1958 , p. 20159
参考文献
Painter, Thomas O.; Kaszas, Krisztian; Gross, Jacklyn; Douglas, Justin T.; Day, Victor W.; Iadarola, Michael J.; Santini, Conrad
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 3 p. 963 - 968
参考文献
Imperial Chemical Industries, PLC
Patent: US5599814 A1, 1997 ;
反应条件
in methanol; dichloromethane
参考文献
Rhone-Poulenc Argriculture Limited
Patent: US5658858 A1, 1997 ;
反应条件
in diethyl ether 1 h; Inert atmosphere;
参考文献
Levesque, Patrick; Fournier, Pierre-Andre
Journal of Organic Chemistry, 2010 , vol. 75, # 20 p. 7033 - 7036
反应条件
1: aqueous hydrochloric acid 2: aqueous HCl 3: POCl3; PCl5 View Scheme
参考文献
Van Horn, Kurt S.; Zhu, Xiaohua; Pandharkar, Trupti; Yang, Sihyung; Vesely, Brian; Vanaerschot, Manu; Dujardin, Jean-Claude; Rijal, Suman; Kyle, Dennis E.; Wang, Michael Zhuo; Werbovetz, Karl A.; Manetsch, Roman
Journal of Medicinal Chemistry, 2014 , vol. 57, # 12 p. 5141 - 5156
反应条件
in ethylene glycol dimethyl ether; ethylene glycol diethyl ether T=0°C; 2 h; Inert atmosphere;
参考文献
Mangas-Sanchez, Juan; Busto, Eduardo; Gotor-Fernandez, Vicente; Gotor, Vicente
Organic Letters, 2012 , vol. 14, # 6 p. 1444 - 1447
