反-1,2-环己烷二甲酸合成路线 （共 51 条）
反应条件
1.1: ethanol / 6.5 h / -70 - 20 °C / Resolution of racemate 2.1: hydrogenchloride / water 3.1: sulfuric acid / 18 h / 40 °C 4.1: diisobutylaluminium hydride / toluene / 6 h / -5 - 20 °C / Inert atmosphere 4.2: 13 h / -5 - 40 °C View Scheme
参考文献
CADILA HEALTHCARE LIMITED; DWIVEDI, Shri Prakash Dhar; SINGH, Ramesh Chandra; CHAVDA, Rajendra Gokalbhai
Patent: WO2013/121440 A1, 2013 ;
反应条件
1: ethanol / 6.5 h / -70 - 20 °C / Resolution of racemate 2: hydrogenchloride / water 3: sulfuric acid / 18 h / 40 °C View Scheme
参考文献
RANBAXY LABORATORIES LIMITED; JAYACHANDRA, Suresh, Babu; GAHLOT, Udaibhan, Singh; SINGH, Tarun, Kumar; KHANDURI, Chandra, Has
Patent: WO2012/131606 A1, 2012 ;
参考文献
Price; Schwarcz
Journal of the American Chemical Society, 1940 , vol. 62, p. 2891,2894
反应条件
trifluoroacetic anhydride
参考文献
Schneider, Manfred; Engel, Norbert; Hoenicke, Petra; Heinemann, Gerd; Goerisch, Helmut
Angewandte Chemie, 1984 , vol. 96, # 1 p. 55 - 56
反应条件
1: (CF3CO)2O 2: methanol View Scheme
参考文献
Angewandte Chemie, , vol. 96, # 1 p. 55 - 56
反应条件
sulfuric acid dl-trans-hexahydro-phthalic acid diethyl ester;
参考文献
v. Auwers; Ottens
Chemische Berichte, 1924 , vol. 57, p. 438,442
反应条件
acetyl chloride 4 h; Heating;
参考文献
Goodridge, Richard J.; Hambley, Trevor W.; Ridley, Damon D.
Australian Journal of Chemistry, 1986 , vol. 39, # 4 p. 591 - 604
反应条件
1: 96 percent / camphorsulfonic acid / Heating 2: 43 percent / diethyl ether View Scheme
参考文献
Saito, Katsuhiro; Horie, Yoichi; Mukai, Toshio; Toda, Takashi
Bulletin of the Chemical Society of Japan, 1985 , vol. 58, # 11 p. 3118 - 3124
反应条件
(S)-1-phenyl-ethylamine in ethanol; toluene Heating;
参考文献
Ma, Linge; Du, Da-Ming; Xu, Jiaxi
Journal of Organic Chemistry, 2005 , vol. 70, # 24 p. 10155 - 10158
反应条件
FS-Hydrodex β-6TBDM column Resolution of racemate;
参考文献
Mueller, Christian E.; Zell, Daniela; Hrdina, Radim; Wende, Raffael C.; Wanka, Lukas; Schuler, Soeren M. M.; Schreiner, Peter R.
Journal of Organic Chemistry, 2013 , vol. 78, # 17 p. 8465 - 8484
