4-三氟甲基-N-甲基苯胺合成路线 （共 14 条）
反应条件
pyridine; copper diacetate in 1,4-dioxane Chan-Lam reaction; 4.5 h; Reflux;
参考文献
Gonzalez, Israel; Mosquera, Jesus; Guerrero, Cesar; Rodriguez, Ramon; Cruces, Jacobo
Organic Letters, 2009 , vol. 11, # 8 p. 1677 - 1680
反应条件
dihydrogen peroxide; disodium 2,3-dihydroxysuccinate; 5,10,15,20-Ph4-21H,23H-porphine-p,p',p'',p'''-(SO4)4*FeCl3 in water; acetonitrile T=25°C; oxidative N-demethylation; pH=4;
参考文献
Baciocchi, Enrico; Gerini, M. Francesca; Lanzalunga, Osvaldo; Lapi, Andrea; Lo Piparo, Maria Grazia; Mancinelli, Simona
European Journal of Organic Chemistry, 2001 , # 12 p. 2305 - 2310
反应条件
triethylsilane; tin(IV) chloride in dichloromethane T=0 - 5°C; Rearrangement; Reduction;
参考文献
Lopez, Francisco J.; Nitzan, Dov
Tetrahedron Letters, 1999 , vol. 40, # 11 p. 2071 - 2074
反应条件
lignin peroxidase from Phanerochaete chrysosporium; sodium tartrate buffer; dihydrogen peroxide in acetonitrile T=25°C; Oxidative N-demethylation; pH=4; Title compound not separated from byproducts;
参考文献
Chemical Communications, , # 5 p. 393 - 394
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=60°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 10 p. 2621 - 2627
反应条件
sodium t-butanolate in toluene T=65°C; Buchwald-Hartwig amination; Inert atmosphereSealed vial;
参考文献
Chemistry - A European Journal, , vol. 16, # 6 p. 1983 - 1991
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 12 h; Further byproducts given. Title compound not separated from byproducts;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 76, # 5 p. 1063 - 1070
反应条件
lead(IV) acetate; 2-hydroxy-1,3-isoindolinedione; acetic acid in acetonitrile T=25°C; 10 h;
参考文献
Journal of Organic Chemistry, , vol. 70, # 13 p. 5144 - 5149
反应条件
1: DIEA; DMAP / tetrahydrofuran / 25 °C 2: LiAlH4 / tetrahydrofuran / 60 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 10 p. 2621 - 2627
反应条件
sodium tetrahydroborate in dimethyl sulfoxide
参考文献
Journal of Organic Chemistry, , vol. 75, # 5 p. 1378 - 1385
