1-乙酰基-2-(4-硝基苯甲酰)肼合成路线 （共 8 条）
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=10 - 20°C;
参考文献
FOREST LABORATORIES HOLDINGS LIMITED
Patent: US2009/239848 A1, 2009 ;
Location in patent: Page/Page column 21 ;
US 20090239848 A1
反应条件
N,N-dimethyl acetamide T=0°C; 6 h; Inert atmosphere;
参考文献
Conole, Daniel; Beck, Thorsten M.; Jay-Smith, Morgan; Tingle, Malcolm D.; Eason, Charles T.; Brimble, Margaret A.; Rennison, David
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 7 p. 2220 - 2235
反应条件
1: hydrazine hydrate / methanol / 0.5 h / |Reflux; |Inert atmosphere 2: N,N-dimethyl acetamide / 6 h / 0 °C / |Inert atmosphere View Scheme
参考文献
Conole, Daniel; Beck, Thorsten M.; Jay-Smith, Morgan; Tingle, Malcolm D.; Eason, Charles T.; Brimble, Margaret A.; Rennison, David
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 7 p. 2220 - 2235
参考文献
Horwitz; Grakauskas
Journal of Organic Chemistry, 1954 , vol. 19, p. 194,198
参考文献
Silberg; Cosma
Acad. Repub. Pop. Rom., Fil. Cluj, Stud. Cercet. Chim., 1959 , vol. 10, p. 151,160
Chem.Abstr., 1960 , p. 8794
反应条件
1: trichlorophosphate / 20 h / 80 °C / |Inert atmosphere 2: Na2S*9H2O / 1,4-dioxane; water / 0.75 h / 80 °C / |Inert atmosphere View Scheme
参考文献
Conole, Daniel; Beck, Thorsten M.; Jay-Smith, Morgan; Tingle, Malcolm D.; Eason, Charles T.; Brimble, Margaret A.; Rennison, David
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 7 p. 2220 - 2235
反应条件
1: With trichlorophosphate
T=110°C; 6 h; Inert atmosphere;
2: With sodium hydroxide in water
参考文献
FOREST LABORATORIES HOLDINGS LIMITED
Patent: US2009/239848 A1, 2009 ;
Location in patent: Page/Page column 21 ;
US 20090239848 A1
反应条件
triethylamine
10 h; Heating;
参考文献
Rigo, Benoit; Fasseur, Dominique; Cauliez, Pascal; Couturier, Daniel
Synthetic Communications, 1989 , vol. 19, # 13-14 p. 2321 - 2336
