2-甲基-5-(4-硝基苯基)-1,3,4-噁二唑合成路线 （共 15 条）
反应条件
Na2S*9H2O in 1,4-dioxane; water T=80°C; 0.75 h; Inert atmosphere;
参考文献
Conole, Daniel; Beck, Thorsten M.; Jay-Smith, Morgan; Tingle, Malcolm D.; Eason, Charles T.; Brimble, Margaret A.; Rennison, David
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 7 p. 2220 - 2235
反应条件
1: With trichlorophosphate
T=110°C; 6 h; Inert atmosphere;
2: With sodium hydroxide in water
参考文献
FOREST LABORATORIES HOLDINGS LIMITED
Patent: US2009/239848 A1, 2009 ;
Location in patent: Page/Page column 21 ;
US 20090239848 A1
反应条件
dicyclohexyl-carbodiimide in toluene
T=120°C; 0.25 h;
参考文献
Povazanec, Frantisek; Kovac, Jaroslav; Svoboda, Jozef
Collection of Czechoslovak Chemical Communications, 1980 , vol. 45, # 4 p. 1299 - 1300
反应条件
ammonium cerium(IV) nitrate; water in acetonitrile
T=23°C; 1.1 h;
参考文献
Somogyi, Laszlo
Journal of Heterocyclic Chemistry, 2007 , vol. 44, # 6 p. 1235 - 1246
反应条件
trichlorophosphate
T=80°C; 0.333333 h;
参考文献
Li, Qiang; Tao, Yi; Xu, Dongfang; Zhang, Haobing; Duan, Liping
Journal of the Chinese Chemical Society, 2014 , vol. 61, # 6 p. 665 - 670
反应条件
toluene-4-sulfonic acid
15 h; Heating;
参考文献
Peet, Norton P.; Sunder, Shyam
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 1807 - 1816
反应条件
T=100°C; 1 h; Microwave irradiation;
参考文献
Efimova; Artamonova; Koldobskii
Russian Journal of Organic Chemistry, 2008 , vol. 44, # 9 p. 1345 - 1347
反应条件
1: 74 percent / hydrazine hydrate / ethanol / 15 h / Heating
2: 90 percent / p-toluenesulfonic acid / 15 h / Heating
View Scheme
参考文献
Peet, Norton P.; Sunder, Shyam
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 1807 - 1816
反应条件
triethylamine
10 h; Heating;
参考文献
Rigo, Benoit; Fasseur, Dominique; Cauliez, Pascal; Couturier, Daniel
Synthetic Communications, 1989 , vol. 19, # 13-14 p. 2321 - 2336
参考文献
Jursic; Zdravkovski
Synthetic Communications, 1994 , vol. 24, # 11 p. 1575 - 1582
