4-氯-2-羟基苯甲酸甲酯合成路线 （共 19 条）
反应条件
1: NH2OH*HCl, aq. NaOH 2: carbonyldiimidazole / tetrahydrofuran / Heating 3: POCl3, Et3N / Heating View Scheme
参考文献
Jiangsu Guohua Investment Co., Ltd; Shanghai Institute of Pharmaceutical Industry
Patent: EP2322520 A1, 2011 ;
反应条件
hydroxylamine hydrochloride; sodium methylate in methanol
参考文献
American Cyanamid Company
Patent: US5484763 A1, 1996 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=20°C; 0.5 h;
参考文献
Naganawa, Atsushi; Saito, Tetsuji; Nagao, Yuuki; Egashira, Hiromu; Iwahashi, Maki; Kambe, Tohru; Koketsu, Masatoshi; Yamamoto, Hiroshi; Kobayashi, Michiyoshi; Maruyama, Takayuki; Ohuchida, Shuichi; Nakai, Hisao; Kondo, Kigen; Toda, Masaaki
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 16 p. 5562 - 5577
反应条件
in tetrahydrofuran; water; argon
参考文献
Ono Pharmaceutical Co., Ltd.
Patent: US6448290 B1, 2002 ;
反应条件
hydrazine in water
T=20°C;
参考文献
Jolivalt; Neuville; Boyer; Kerhoas; Mougin
Journal of Agricultural and Food Chemistry, 2006 , vol. 54, # 14 p. 5046 - 5054
反应条件
1: Et3N / CH2Cl2 / -78 - 20 °C
2: Cs2CO3; rac-2,2'-bis(diphenylphosphino)-1,1'-binaphthalene / Pd(OAc)2 / toluene / 16 h / 120 °C
3: barium hydroxide octahydrate / methanol / 90 °C
4: POCl3 / 2 h / 120 °C
View Scheme
参考文献
Anderson, Marc O.; Sherrill, John; Madrid, Peter B.; Liou, Ally P.; Weisman, Jennifer L.; DeRisi, Joseph L.; Guy, R. Kiplin
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 2 p. 334 - 343
反应条件
potassium carbonate in acetone
24 h; Heating / reflux;
参考文献
Venkatesan, Aranapakam Mudumbai; Santos, Osvaldo Dos; Gu, Yansong
Patent: US2005/4162 A1, 2005 ;
Location in patent: Page/Page column 12 ;
US 20050004162 A1
反应条件
1: With hydroxylamine hydrochloride; sodium hydroxide in ethanol; water
T=20°C; 24 h; Cooling with iceInert atmosphere;
2: With hydrogenchloride
0.5 h; Reflux;
参考文献
Jiangsu Guohua Investment Co., Ltd; Shanghai Institute of Pharmaceutical Industry
Patent: EP2322520 A1, 2011 ;
Location in patent: Page/Page column 12 ;
反应条件
hydroxylamine hydrochloride; sodium methylate in methanol
参考文献
American Cyanamid Company
Patent: US5484763 A1, 1996 ;
