4-氨基苯-1,2-二羧酸二乙酯合成路线 （共 16 条）
反应条件
sodium tetrahydroborate; iron(II) chloride in ethanol 3 h; Heating;
参考文献
Ulbrich, Holger K.; Luxenburger, Andreas; Prech, Philip; Eriksson, Einar E.; Soehnlein, Oliver; Rotzius, Pierre; Lindbom, Lennart; Dannhardt, Gerd
Journal of Medicinal Chemistry, 2006 , vol. 49, # 20 p. 5988 - 5999
反应条件
sulfuric acid in dichloromethane 12 h; Reflux;
参考文献
Greig, Iain R.; Coste, Emmanuel; Ralston, Stuart H.; Van 'T Hof, Robert J.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 3 p. 816 - 820
反应条件
1: 78 percent / HCl(g) / 72 h / 80 °C 2: 75 percent / hydrogen / 10 percent Pd on charcoal / ethanol / 5 h / 20 °C / 1551.44 Torr View Scheme
参考文献
Nandy, Partha; Avramis, Vassilios I.; Lien, Eric J.
Medicinal Chemistry Research, 1995 , vol. 5, # 9 p. 664 - 679
反应条件
1: 81 percent 2: 27 percent / H2 / PtO2 View Scheme
参考文献
Leblois, Danielle; Piessard, Sylvie; Baut, Guillaume Le; Kumar, Piyush; Brion, Jean-Daniel; et al.
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 229 - 238
反应条件
1: 92 percent / nitration reaction 2: 81 percent 3: 27 percent / H2 / PtO2 View Scheme
参考文献
Leblois, Danielle; Piessard, Sylvie; Baut, Guillaume Le; Kumar, Piyush; Brion, Jean-Daniel; et al.
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 229 - 238
参考文献
Baeyer
Chemische Berichte, 1877 , vol. 10, p. 1079
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Miller
Chemische Berichte, 1878 , vol. 11, p. 1191
Justus Liebigs Annalen der Chemie, 1881 , vol. 208, p. 236
反应条件
1: diluted sulfuric acid; NaNO2 / Diazotization.man erwaermt auf 60grad und schliesslich auf 100grad 2: concentrated KOH-solution 3: 200 °C View Scheme
参考文献
Baeyer
Chemische Berichte, 1877 , vol. 10, p. 1079
反应条件
1: aqueous HCl; aqueous NaNO2 2: aqueous NaOH View Scheme
参考文献
Gut
Collection of Czechoslovak Chemical Communications, 1956 , vol. 21, p. 1648
反应条件
1: aqueous HCl; aqueous NaNO2 2: aqueous NaOH 3: 180 °C / 0.5 Torr View Scheme
参考文献
Gut
Collection of Czechoslovak Chemical Communications, 1956 , vol. 21, p. 1648
反应条件
1: diluted sulfuric acid; NaNO2 / Diazotization.man erwaermt auf 60grad und schliesslich auf 100grad 2: concentrated KOH-solution View Scheme
参考文献
Chemische Berichte, , vol. 10, p. 1079
