1.1: 96 percent / hydrogen / [RuBr2((R)-SYNPHOS)] / 0.5 h / 50 °C / 7500.6 Torr 2.1: 94 percent / 2,6-lutidine / CH2Cl2 / 0.75 h / -25 - -15 °C 3.1: 71 percent / diisobutylaluminium hydride / CH2Cl2 / 3.5 h / -78 °C 4.1: LDA / tetrahydrofuran; diethyl ether / 0.5 h / -78 °C 4.2: 87 percent / tetrahydrofuran; diethyl ether / 3 h / -78 - 0 °C 5.1: 95 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 20 °C 6.1: 73 percent / quinoline; hydrogen / palladium on BaSO4 / ethyl acetate / 3 h / 20 °C / 750.06 Torr 7.1: 82 percent / triethylamine / CH2Cl2 / 0 - 20 °C 8.1: 78 percent / bis(tricyclohexylphosphine) benzylidene Ru(IV) dichloride / CH2Cl2 / 6 h / Heating View Scheme

1: pentan-2-one; potassium carbonate / Erwaermen des Reaktionsprodukts mit wss.-methanol. Kalilauge 3: Raney nickel; methanol / Hydrogenation.unter Druck View Scheme

water in methanol T=270°C; var. temp.; Product distribution;

methanol; nickel T=210°C; P=102971 Torr; Hydrogenation.Behandlung des Reaktionsprodukts mit warmer aethanol.Kalilauge;

water; sodium methylate in methanol T=20°C; 18 h;

calcium hydroxide powder in dichloromethane; ammonia; butanone

diazomethyl-trimethyl-silane in diethyl ether; benzene 0.666667 h;

1: mono-methyl malonate potassium salt With triethylamine; magnesium chloride in acetonitrile T=20°C; 3 h; 2: n-pentylcarbonyl chloride With triethylamine in acetonitrile T=20°C; 20 h; Further stages.;

methanol; water; oxygen; toluene-4-sulfonic acid; palladium dichloride in N,N-dimethyl acetamide T=80°C; P=4560.31 Torr; 3 h; Autoclave; Reagent/catalystSolventTimePressureConcentration; regioselective reaction;

in methanol; diethyl ether; benzene 0.5 h;