N,N’-双(2-氯乙基)脲合成路线 （共 10 条）
参考文献
Justus Liebigs Annalen der Chemie, , vol. 562, p. 75,1114
反应条件
in dichloromethane 1) 0 deg C, 20 min; 2) room temperature, 18 h;
参考文献
Lunn; Sansone; Andrews; Hellwig
Journal of Pharmaceutical Sciences, 1989 , vol. 78, # 8 p. 652 - 659
反应条件
triethylamine in acetonitrile Ambient temperature;
参考文献
Takeda, Kazuyoshi; Akagi, Yoshie; Saiki, Atsuko; Tsukahara, Toshiko; Ogura, Haruo
Tetrahedron Letters, 1983 , vol. 24, # 42 p. 4569 - 4572
反应条件
acetone T=-10°C; zuletzt bei 30grad;
反应条件
potassium hydroxide; nickel monoaluminide in methanol degradation under various conditions (HBr in glac. CH3CO2H) with preparation of nonmutagenic reaction mixtures of products; Product distributionMechanism;
参考文献
Journal of Pharmaceutical Sciences, , vol. 78, # 8 p. 652 - 659
反应条件
tin(IV) chloride; sodium nitrite in dichloromethane T=20°C; 2 h;
参考文献
Celaries, Benoit; Parkanyi, Cyril
Synthesis, 2006 , # 14 p. 2371 - 2375
反应条件
1: NaI / acetone / Heating 2: NaNO2, HCO2H View Scheme
参考文献
Johnston; McCaleb; Opliger; Montgomery
Journal of medicinal chemistry, 1966 , vol. 9, # 6 p. 892 - 911
参考文献
Johnston; McCaleb; Opliger; Montgomery
Journal of medicinal chemistry, 1966 , vol. 9, # 6 p. 892 - 911
反应条件
1: 72 percent / H2O / Heating
2: 45 percent / n-butyl nitrite, sodium methoxide / diethyl ether / 12 h / Ambient temperature
3: HCl(g) / diethyl ether / 0.5 h / 0 - 4 °C
View Scheme
参考文献
Lown; Chauhan
Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 270 - 279
反应条件
1: 72 percent / H2O / Heating
2: 45 percent / n-butyl nitrite, sodium methoxide / diethyl ether / 12 h / Ambient temperature
View Scheme
参考文献
Lown; Chauhan
Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 270 - 279
