2,5-二溴-4-硝基吡啶合成路线 （共 3 条）
反应条件
phosphorus tribromide T=0 - 5°C; 7 h;
参考文献
Buckman, Brad Owen; Nicholas, John Beamond; Ramphal, Johnnie Y.; Emayan, Kumaraswamy; Seiwert, Scott D.
Patent: US2014/94456 A1, 2014 ;
Location in patent: Paragraph 0832; 0835 ;
反应条件
1: sulfuric acid; nitric acid / 2 h / 100 °C 2: phosphorus tribromide / 7 h / 0 - 5 °C View Scheme
参考文献
Buckman, Brad Owen; Nicholas, John Beamond; Ramphal, Johnnie Y.; Emayan, Kumaraswamy; Seiwert, Scott D.
Patent: US2014/94456 A1, 2014 ;
反应条件
in tetrahydrofuran T=0 - 20°C; Bartoli reaction; Inert atmosphere;
参考文献
Giblin, Gerard M. P.; Billinton, Andrew; Briggs, Michael; Brown, Andrew J.; Chessell, Iain P.; Clayton, Nick M.; Eatherton, Andrew J.; Goldsmith, Paul; Haslam, Carl; Johnson, Matthew R.; Mitchell, William L.; Naylor, Alan; Perboni, Alcide; Slingsby, Brian P.; Wilson, Alex W.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 19 p. 5785 - 5788
