N,N-二异丙基氨基硼烷合成路线 （共 54 条）
反应条件
1: tBuCH2CH2B(H)NiPr2; 3-methoxy benzene diazonium tetrafluoroborate With biscyclopentadienyliron(II) in acetonitrile T=20°C; 2.5 h; 2: With methanol in acetonitrile T=0 - 20°C; 1 h; 3: 2,3-dimethylbutane-2,3-diol in diethyl ether; acetonitrile T=20°C; 4 h; Reagent/catalyst;
参考文献
WO2014/9169 A1, ;
Page/Page column 55 ;
反应条件
1: tBuCH2CH2B(H)NiPr2; tetrafluoroborate of 3-trifluoromethylbenzenediazonium With bis(cyclopentadienyl)titanium dichloride in acetonitrile T=20°C; 2.5 h; 2: With methanol in acetonitrile T=0 - 20°C; 1 h; 3: 2,3-dimethylbutane-2,3-diol in diethyl ether; acetonitrile T=20°C; 4 h; Reagent/catalyst;
参考文献
UNIVERSITE DE BORDEAUX 1; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; PUCHEAULT, Mathieu Jonathan Damien; MARCIASINI, Ludovic Daniel Alain; VAULTIER, Michel
Patent: WO2014/9169 A1, 2014 ;
Location in patent: Page/Page column 53-54; 67-68 ;
反应条件
1: tBuCH2CH2B(H)NiPr2; 1,2-dichloro-4-diazoniumbenzene tetrafluoroborate With bis(cyclopentadienyl)titanium dichloride in acetonitrile T=20°C; 2.5 h; 2: With methanol in acetonitrile T=0 - 20°C; 1 h; 3: 2,3-dimethylbutane-2,3-diol in diethyl ether; acetonitrile T=20°C; 4 h; Reagent/catalyst;
参考文献
UNIVERSITE DE BORDEAUX 1; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; PUCHEAULT, Mathieu Jonathan Damien; MARCIASINI, Ludovic Daniel Alain; VAULTIER, Michel
Patent: WO2014/9169 A1, 2014 ;
Location in patent: Page/Page column 53-54; 67-68 ;
反应条件
1: 3-iodobenzenediazonium tetrafluoroborate; tBuCH2CH2B(H)NiPr2 With biscyclopentadienyliron(II) in acetonitrile T=20°C; 2.5 h; 2: With methanol in acetonitrile T=0 - 20°C; 1 h; 3: 2,3-dimethylbutane-2,3-diol in diethyl ether; acetonitrile T=20°C; 4 h; Reagent/catalyst;
参考文献
UNIVERSITE DE BORDEAUX 1; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; PUCHEAULT, Mathieu Jonathan Damien; MARCIASINI, Ludovic Daniel Alain; VAULTIER, Michel
Patent: WO2014/9169 A1, 2014 ;
Location in patent: Page/Page column 64 ;
反应条件
1: tBuCH2CH2B(H)NiPr2; 4-methoxybenzenediazonium tetrafluoroborate With biscyclopentadienyliron(II) in acetonitrile T=20°C; 2.5 h; 2: With methanol in acetonitrile T=0 - 20°C; 1 h; 3: 2,3-dimethylbutane-2,3-diol in diethyl ether; acetonitrile T=20°C; 4 h; SolventReagent/catalystConcentration;
参考文献
UNIVERSITE DE BORDEAUX 1; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; PUCHEAULT, Mathieu Jonathan Damien; MARCIASINI, Ludovic Daniel Alain; VAULTIER, Michel
Patent: WO2014/9169 A1, 2014 ;
Location in patent: Page/Page column 55-56 ;
反应条件
1: 4-methoxy-aniline With boron trifluoride diethyl etherate; isopentyl nitrite in acetonitrile T=0°C; 0.333333 h; 2: tBuCH2CH2B(H)NiPr2 in acetonitrile T=20°C; 3 h; 3: 2,3-dimethylbutane-2,3-diol With methanol in acetonitrile T=20°C; 5 h;
参考文献
UNIVERSITE DE BORDEAUX 1; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; PUCHEAULT, Mathieu Jonathan Damien; MARCIASINI, Ludovic Daniel Alain; VAULTIER, Michel
Patent: WO2014/9169 A1, 2014 ;
Location in patent: Page/Page column 51-52 ;
反应条件
catalyst: Pd#1,1'-bis(diphenylphosphino)ferrocene; triethylamine; CH3OH in diethyl ether byproducts: CH3OC6H5; 1. BH2N(CH(CH3)2)2, CH3OC6H4Br, (Pd), (C2H5)3N, toluene, 100°C, 1h; 2. CH3OH, room temp., 1 h; 3. pinacol, (C2H5)2O, room temp., 4 h;
参考文献
Gendrineau, Thomas; Marre, Samuel; Vaultier, Michel; Pucheault, Mathieu; Aymonier, Cyril
Angewandte Chemie - International Edition, 2012 , vol. 51, # 34 p. 8525 - 8528
反应条件
1: tBuCH2CH2B(H)NiPr2; cyclohexyl magnesium bromide in tetrahydrofuran T=0°C; 1 h; Inert atmosphere; 2: water With hydrogenchloride in tetrahydrofuran T=0°C; 0.583333 h; Inert atmosphere;
参考文献
Bailey, Christopher L.; Murphy, Chris L.; Clary, Jacob W.; Eagon, Scott; Gould, Naomi; Singaram, Bakthan
Heterocycles, 2012 , vol. 86, # 1 p. 331 - 341
反应条件
in tetrahydrofuran T=65°C; 15 h;
参考文献
Haddenham, Dustin; Bailey, Christopher L.; Vu, Chau; Nepomuceno, Gabby; Eagon, Scott; Pasumansky, Lubov; Singaram, Bakthan
Tetrahedron, 2011 , vol. 67, # 3 p. 576 - 583
反应条件
1: tBuCH2CH2B(H)NiPr2; cyano derivative of benzenediazonium tetrafluoroborate With bis(cyclopentadienyl)titanium dichloride in acetonitrile T=20°C; 2.5 h; 2: With methanol in acetonitrile T=0 - 20°C; 1 h; 3: 2,3-dimethylbutane-2,3-diol in diethyl ether; acetonitrile T=20°C; 4 h; Reagent/catalyst;
参考文献
WO2014/9169 A1, ;
Page/Page column 53-54; 67-68 ;
