4-(4-溴苯基)-2-甲基噁唑合成路线 （共 4 条）
反应条件
1: T=130°C; 2.5 h; Neat (no solvent); 2: With sodium hydroxide in diethyl ether; water
参考文献
GLAXO GROUP LIMITED
Patent: WO2005/40144 A1, 2005 ;
Location in patent: Page/Page column 13-14 ;
WO 2005/040144 A1
反应条件
1: potassium iodide; copper(l) iodide / ethylenediamine / 120 °C / |Inert atmosphere 2: copper(l) iodide; potassium carbonate / N,N-dimethyl-formamide / 120 °C / |Inert atmosphere View Scheme
参考文献
Liang, Hao; Ren, Zhi-Hui; Wang, Yao-Yu; Guan, Zheng-Hui
Chemistry - A European Journal, 2013 , vol. 19, # 30 p. 9789 - 9794
反应条件
in 1-methyl-pyrrolidin-2-one 2.5 h; Heating / reflux; Product distribution / selectivity;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/40192 A1, 2006 ;
Location in patent: Page/Page column 37 ;
WO 2006/040192 A1
反应条件
1: Br2 / CCl4 / 0.5 h / Ambient temperature
2: 3-cyclohexene carboxylic acid, N2O4 / CH2Cl2 / Ambient temperature; overnight
View Scheme
参考文献
Hammar; Rustad
Journal of Heterocyclic Chemistry, 1981 , vol. 18, # 5 p. 885 - 888
