1-氨基-1-苯基环己烷合成路线 （共 22 条）
反应条件
n-butyllithium in hexane 72 h; Heating;
参考文献
Journal of Organic Chemistry, , vol. 48, # 21 p. 3822 - 3825
参考文献
Thurkauf, Andrew; Costa, Brian de; Yamaguchi, Shun-ichi; Mattson, Mariena V.; Jacobson, Arthur E.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1452 - 1458
反应条件
formic acid Heating;
参考文献
Thurkauf, Andrew; Costa, Brian de; Yamaguchi, Shun-ichi; Mattson, Mariena V.; Jacobson, Arthur E.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1452 - 1458
参考文献
Johnston; McCaleb; Opliger; Montgomery
Journal of medicinal chemistry, 1966 , vol. 9, # 6 p. 892 - 911
参考文献
Journal of the American Chemical Society, , vol. 49, p. 1102
反应条件
lithium aluminium tetrahydride in diethyl ether
T=20°C; 3 h; Inert atmosphere;
参考文献
Tagad, Harichandra D.; Hamada, Yoshio; Nguyen, Jeffrey-Tri; Hidaka, Koushi; Hamada, Takashi; Sohma, Youhei; Kimura, Tooru; Kiso, Yoshiaki
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 17 p. 5238 - 5246
反应条件
hydrogen; palladium 10 on activated carbon in methanol
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/49952 A1, 2006 ;
Location in patent: Page/Page column 61-62 ;
反应条件
sodium dithionite; potassium carbonate; N,N'-dioctyl-4,4'-bipyridinium in water; acetonitrile
T=35°C; 24 h;
参考文献
Park, Kwanghee Koh; Oh, Chang Hun; Sim, Woo-Jeon
Journal of Organic Chemistry, 1995 , vol. 60, # 19 p. 6202 - 6204
反应条件
sodium hydroxide in methanol
7 h; Reflux;
参考文献
Miyoshi, Tetsuya; Matsuya, Syota; Tsugawa, Mikako; Sato, Shohei; Ueda, Masafumi; Miyata, Okiko
Organic Letters, 2013 , vol. 15, # 13 p. 3374 - 3377
反应条件
hydrogenchloride; triphenylphosphine in 1,4-dioxane; diethyl ether; acetonitrile
参考文献
Pfizer Inc
Patent: US6130217 A1, 2000 ;
US 6130217 A
