2-(甲氧基甲基)苯甲醚合成路线 （共 16 条）
反应条件
n-butyllithium; water 1.) hexane/THF; Yield given. Multistep reaction;
参考文献
Azzena, Ugo; Demartis, Salvatore; Fiori, Maria Giovanna; Melloni, Giovanni; Pisano, Luisa
Tetrahedron Letters, 1995 , vol. 36, # 31 p. 5641 - 5644
反应条件
caesium carbonate; dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; palladium diacetate in 1,4-dioxane; water
T=100°C;
参考文献
Eisai RandD Management Co., Ltd.
Patent: EP1867650 A1, 2007 ;
Location in patent: Page/Page column 35-36 ;
反应条件
sodium hydroxide; tetrabutylammomium bromide in dichloromethane
T=40°C; 45 h;
参考文献
Buchanan, David H.; Takemura, Nobumi; Sy, James N. O.
Journal of Organic Chemistry, 1986 , vol. 51, # 22 p. 4291 - 4294
反应条件
Decaborane
T=20°C; reductive etherification; 6 h;
参考文献
Lee, Seung Hwan; Park, Yong June; Yoon, Cheol Min
Tetrahedron Letters, 1999 , vol. 40, # 33 p. 6049 - 6050
反应条件
4,4'-di-tert-butylbiphenyl; lithium in tetrahydrofuran
T=-78°C; 1 h;
参考文献
Gomez, Cecilia; Macia, Beatriz; Lillo, Victor J.; Yus, Miguel
Tetrahedron, 2006 , vol. 62, # 42 p. 9832 - 9839
反应条件
1: 1-hydroxymethyl-2-methoxy-benzene With titanium tetrachloride in chloroform
T=20°C; 0.0166667 h; Molecular sieve;
2: methanol in chloroform
48 h; Reflux;
参考文献
Tsai, Chen-Yu; Sung, Robert; Zhuang, Bo-Ren; Sung, Kuangsen
Tetrahedron, 2010 , vol. 66, # 34 p. 6869 - 6872
反应条件
bis-triphenylphosphine-palladium(II) chloride in N,N,N',N',N'',N''-hexamethylphosphoric triamide
T=80°C; 70 h; Yield given;
参考文献
Kosugi, Masanori; Sumiya, Takashi; Ogata, Toshimi; Sano, Hiroshi; Migita, Toshihiko
Chemistry Letters, 1984 , p. 1225 - 1226
反应条件
methanol; potassium carbonate
参考文献
Gutsche; Johnson
Journal of the American Chemical Society, 1955 , vol. 77, p. 109,112
Org. Synth. Coll., 1963 , vol. Vol. IV, p. 780,782
反应条件
1: sulfuryl chloride / CH2Cl2 / -78 °C
2: lithium; 4,4'-di-tert-butylbiphenyl / tetrahydrofuran / 1 h / -78 °C
View Scheme
参考文献
Gomez, Cecilia; Macia, Beatriz; Lillo, Victor J.; Yus, Miguel
Tetrahedron, 2006 , vol. 62, # 42 p. 9832 - 9839
反应条件
1: 77 percent / sodium iodide; sodium hydride / tetrahydrofuran / 0 - 20 °C
2: sulfuryl chloride / CH2Cl2 / -78 °C
3: lithium; 4,4'-di-tert-butylbiphenyl / tetrahydrofuran / 1 h / -78 °C
View Scheme
参考文献
Gomez, Cecilia; Macia, Beatriz; Lillo, Victor J.; Yus, Miguel
Tetrahedron, 2006 , vol. 62, # 42 p. 9832 - 9839
