2,4-二甲基-3-吡咯羧酸乙酯合成路线 （共 45 条）
反应条件
1.1: trichlorophosphate / dichloromethane / 1.25 h / 4 °C / Reflux 1.2: 10 °C 2.1: potassium hydroxide / water / 5 h / Reflux 2.2: pH 4 3.1: pyrrolidine / ethanol / 3 h / Reflux View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 52, # 9 p. 360 - 365
反应条件
1.1: trichlorophosphate / 2 - 3 h / 0 - 50 °C 1.2: 25 - 30 °C / pH 12 - 13 2.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C 3.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 0.5 h 3.2: 16 h / 25 - 30 °C 4.1: pyrrolidine / methanol / 5 - 7 h / Reflux 5.1: ethanol / 2 - 4 h / Reflux View Scheme
参考文献
Natco Pharma Limited
Patent: US2011/92717 A1, 2011 ;
反应条件
phosgene; acetic acid
参考文献
Fischer; Schneller
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1923 , vol. 128, p. 230,235, 236
反应条件
1.1: trichlorophosphate / 2 - 3 h / 0 - 50 °C 1.2: 25 - 30 °C / pH 12 - 13 2.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C 3.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 0.5 h 3.2: 16 h / 25 - 30 °C 4.1: pyrrolidine / methanol / 5 - 7 h / Reflux View Scheme
参考文献
Natco Pharma Limited
Patent: US2011/92717 A1, 2011 ;
反应条件
1.1: trichlorophosphate / 2 - 3 h / 0 - 50 °C 1.2: 25 - 30 °C / pH 12 - 13 2.1: potassium hydroxide; water / methanol / 4 - 6 h / 60 - 70 °C 3.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 0.5 h 3.2: 16 h / 25 - 30 °C View Scheme
参考文献
Lv, Kai; Wang, Li-Li; Liu, Ming-Liang; Zhou, Xin-Bo; Fan, Shi-Yong; Liu, Hong-Ying; Zheng, Zhi-Bing; Li, Song
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 10 p. 3062 - 3065
参考文献
Treibs; Reitsam
Justus Liebigs Annalen der Chemie, 1958 , vol. 611, p. 205,222
参考文献
Treibs; Reitsam
Justus Liebigs Annalen der Chemie, 1958 , vol. 611, p. 205,222
参考文献
Treibs; Reitsam
Justus Liebigs Annalen der Chemie, 1958 , vol. 611, p. 205,222
参考文献
Treibs; Reitsam
Justus Liebigs Annalen der Chemie, 1958 , vol. 611, p. 205,222
参考文献
Treibs; Reitsam
Justus Liebigs Annalen der Chemie, 1958 , vol. 611, p. 205,222
