hydrogenchloride; sodium nitrite

sodium hydroxide in ethanol; water T=70°C; 16 h;

potassium acetate; isopentyl nitrite in benzene T=80°C; 20 h;

potassium phosphate; tetrakis(triphenylphosphine) palladium(0); potassium bromide in 1,4-dioxane Suzuki Coupling; 4 h; RefluxInert atmosphere;

1: palladium diacetate; caesium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl / toluene / 18 h / 100 °C / Inert atmosphere 2: sodium hydroxide / ethanol; water / 16 h / 70 °C View Scheme

1: N-chloro-succinimide / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere 2: palladium diacetate; caesium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl / toluene / 18 h / 100 °C / Inert atmosphere 3: sodium hydroxide / ethanol; water / 16 h / 70 °C View Scheme

1: copper(l) iodide; potassium carbonate; N-methyl-2-(methylamino)ethylamine / 1,4-dioxane / 18 h / 90 °C / Inert atmosphere 2: N-chloro-succinimide / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere 3: palladium diacetate; caesium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl / toluene / 18 h / 100 °C / Inert atmosphere 4: sodium hydroxide / ethanol; water / 16 h / 70 °C View Scheme

hydrogenchloride T=100°C; im Rohr;

T=55 - 60°C;

T=100 - 120°C; im Rohr;