1-propanephosphonic acid cyclic anhydride in ethyl acetate T=110°C; Fischer indole synthesis; 0.166667 h; Microwave irradiationSealed vessel;

1: With hydrogenchloride in water T=60°C; 4 h; 2: With sodium hydroxide in water pH=8;

in acetic acid 7 h; Reflux;

1: 1-bromocyclohexane With chloro-trimethyl-silane; magnesium; ethylene dibromide; lithium chloride; zinc dibromide in tetrahydrofuran T=0 - 25°C; 4 h; Inert atmosphere; 2: With zinc dibromide in tetrahydrofuran T=25°C; 0.166667 h; Inert atmosphere; 3: Br-BDT With chloro-trimethyl-silane in tetrahydrofuran T=-60 - 125°C; Inert atmosphereMicrowave irradiation; regioselective reaction;

4-bromo-aniline sulfate

chloranil; xylene

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sodium methylate; copper(l) iodide in N,N-dimethyl-formamide 13 h; Heating;

potassium hydroxide 1.) acetone, 2.) room temp., 8 min; Yield given. Multistep reaction;