4-氯-alpha-甲基苯乙腈合成路线 （共 10 条）
反应条件
sodium cyanide; N-benzyl-N,N,N-triethylammonium chloride in acetonitrile
T=33°C; 45 h;
参考文献
Singh, N. P.; Kumar, A.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 1195 - 1196
反应条件
tris(pentafluorophenyl)-borane in acetonitrile
T=20°C; 1 h;
参考文献
Rajagopal, Gurusamy; Kim, Sung Soo
Tetrahedron, 2009 , vol. 65, # 22 p. 4351 - 4355
反应条件
sodium hydrogen telluride; acetic acid in ethanol; benzene
T=-20°C; 0.333333 h;
参考文献
Blay, Gonzalo; Cardona, Luz; Garcia, Begona; Lahoz, Luisa; Pedro, Jose R.
Tetrahedron, 1996 , vol. 52, # 25 p. 8611 - 8618
反应条件
potassium carbonate
T=180°C; 2.25 h;
参考文献
Selva, Maurizio; Marques, Carlos Alberto; Tundo, Pietro
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 10 p. 1323 - 1328
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Bomben, Andrea; Selva, Maurizio; Tundo, Pietro
Recueil des Travaux Chimiques des Pays-Bas-Journal of the Royal Netherlands, 1996 , vol. 115, # 4 p. 256 - 260
反应条件
1: (p-chlorophenyl)acetonitrile With sodium hydride in tetrahydrofuran; mineral oil
T=0°C; 0.666667 h; Inert atmosphere;
2: methyl iodide in tetrahydrofuran; mineral oil
T=-78 - 20°C; 13.25 h; Inert atmosphere;
参考文献
Ueno, Satoshi; Maeda, Ryohei; Yasuoka, Shohei; Kuwano, Ryoichi
Chemistry Letters, 2013 , vol. 42, # 1 p. 40 - 42
反应条件
1: POCl3, pyridine / benzene
2: 90 percent / NaTeH, AcOH / ethanol; benzene / 0.33 h / -20 °C
View Scheme
参考文献
Blay, Gonzalo; Cardona, Luz; Garcia, Begona; Lahoz, Luisa; Pedro, Jose R.
Tetrahedron, 1996 , vol. 52, # 25 p. 8611 - 8618
反应条件
potassium tert-butylate in methanol
T=200°C; 5 h; other reaction time; Product distribution;
参考文献
Selva, Maurizio; Tundo, Pietro
Journal of Organic Chemistry, 1998 , vol. 63, # 25 p. 9540 - 9544
反应条件
2 h; Ambient temperatureIrradiationphotoinduced decarboxylation;
参考文献
Katagi, Toshiyuki; Mikami, Nobuyoshi; Matsuda, Tadashi; Miyamoto, Junshi
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1989 , p. 779 - 782
反应条件
(i) nBuLi, iPr2NH, THF, hexane, (ii) O2, (iii) /BRN= 605303/; Multistep reaction;
参考文献
Freerksen; Pabst; Raggio; Sherman; Wroble; Watt
Journal of the American Chemical Society, 1977 , vol. 99, # 5 p. 1536 - 1542
反应条件
(i) HCl, EtOH, (ii) NaBH4, LiI*2H2O, MeCN; Multistep reaction;
参考文献
Heeres; Backx; Van Cutsem
Journal of Medicinal Chemistry, 1976 , vol. 19, # 9 p. 1148 - 1155
