(S)-(-)-2-羟基-3,3-二甲基丁酸合成路线 （共 10 条）
反应条件
sodium nitrite in water 1.) room temp., 24 h 2.) 60 degC, 30 min;
参考文献
Hartwig; Schollkopf
1982 , vol. No. 11, p. 1952 - 1970
反应条件
sodium tetrahydroborate esterification with (S)-phenylethylamine and hydrolysis;
参考文献
Zhang,W.Y.; Jakiela,D.J.; Maul,A.
Journal of the American Chemical Society, 1988 , vol. 110, p. 4652
反应条件
dipyridinium dichromate in dichloromethane T=25°C; 2 h;
参考文献
Tetrahedron Asymmetry, , vol. 13, # 1 p. 29 - 36
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.58 h / -78 °C 1.2: 51 percent / tetrahydrofuran; hexane / 1 h / -100 °C 2.1: 67 percent / mercuric acetate; aqueous acetic acid; calcium carbonate / 80 °C / pH 7 3.1: pyridinium dichromate / CH2Cl2 / 2 h / 25 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 13, # 1 p. 29 - 36
反应条件
1: sodium borohydride / methanol; H2O / 1 h / 25 °C 2: 67 percent / mercuric acetate; aqueous acetic acid; calcium carbonate / 80 °C / pH 7 3: pyridinium dichromate / CH2Cl2 / 2 h / 25 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 13, # 1 p. 29 - 36
反应条件
1: 67 percent / mercuric acetate; aqueous acetic acid; calcium carbonate / 80 °C / pH 7 2: pyridinium dichromate / CH2Cl2 / 2 h / 25 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 13, # 1 p. 29 - 36
反应条件
(i) KMnO4, (ii) H2, Raney-Ni, (iii) (racemate resolution using brucine); Multistep reaction;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 41, p. 2178 - 2179
反应条件
hydrogenchloride; sodium nitrite in water 1) 7h, -5 deg C - -3 deg C, 2) 18h, 20 deg C - 25 deg C; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Chemische Berichte, , vol. 124, # 4 p. 849 - 859
反应条件
hydrogenchloride; sodium nitrite in water 1) 7 h, -5 deg C - -3 deg C, 2) 18 h, 20 deg C - 25 deg C; Yield given. Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Chemische Berichte, , vol. 124, # 4 p. 849 - 859
反应条件
1: With sodium hydroxide Heating; 2: With (S)-1-phenyl-ethylamine racemate resolution;
参考文献
Tetrahedron: Asymmetry, , vol. 10, # 11 p. 2087 - 2100
