4-氯-2-甲基嘧啶-5-甲酸乙酯合成路线 （共 11 条）
反应条件
trichlorophosphate 0.5 h; Reflux;
参考文献
AstraZeneca AB
Patent: US2009/264401 A1, 2009 ;
Location in patent: Page/Page column 117-118 ;
反应条件
1: EtONa / ethanol 2: POCl3 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 15 p. 1645 - 1648
参考文献
Dornow; Petsch
Chemische Berichte, 1953 , vol. 86, p. 1404,1406
Full Text Show Details
Todd; Bergel
Journal of the Chemical Society, 1937 , p. 367
Journal of the Chemical Society, 1938 , p. 28
反应条件
1: NH3 2: diethyl ether; LiAlH4 3: SOCl2 View Scheme
参考文献
Dornow; Petsch
Chemische Berichte, 1953 , vol. 86, p. 1404,1406
反应条件
1: NH3 2: diethyl ether; LiAlH4 View Scheme
参考文献
Dornow; Petsch
Chemische Berichte, 1953 , vol. 86, p. 1404,1406
反应条件
1: NH3 2: NH3 3: POCl3 View Scheme
参考文献
Todd; Bergel
Journal of the Chemical Society, 1937 , p. 367
Journal of the Chemical Society, 1938 , p. 28
反应条件
1: 72 percent / sodium / Ambient temperature
2: NaOH / methanol; H2O / 1 h / 65 °C
3: 1.) triethylamine, ethylchloroformate / 1.) THF, 0 deg C, 30 min, 2.) room temp. overnight
View Scheme
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
参考文献
Todd; Bergel
Journal of the Chemical Society, 1937 , p. 367
Journal of the Chemical Society, 1938 , p. 28
反应条件
sodium
Ambient temperature;
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
反应条件
1: 75 percent / sodium / Ambient temperature
2: NaOH / methanol; H2O / 1 h / 65 °C
3: 1.) triethylamine, ethylchloroformate / 1.)THF, 0 deg C, 30 min, 2.) room temp. overnight
View Scheme
参考文献
Dostert; Imbert; Ancher; et al.
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 5 p. 437 - 444
