1: With pyridine in dichloromethane T=-10 - 20°C; Inert atmosphere; 2: With potassium carbonate in methanol; water T=20°C; 1 h; Inert atmosphere; 3: With hydrogenchloride in methanol; water pH=1;
参考文献
ABRAXIS BIOSCIENCE, LLC; TAO, Chunlin; WANG, Qinwei; POLAT, Tulay; NALLAN, Laxman; HO, David; DESAI, Neil
Patent: WO2010/144359 A1, 2010 ;
Location in patent: Page/Page column 129 ;
WO 2010/144359 A1