(4S)-6-氯-4-(环丙基乙炔基)-2-氧代-4-(三氟甲基)-2H-3,1-苯并恶嗪-1(4H)-羧酸甲酯合成路线 (共 2 条)
反应条件
potassium hydrogencarbonate in water; toluene T=20 - 25°C; 8.5 h;
参考文献
MERCK and CO., INC.
Patent: EP968197 B1, 2005 ;
Location in patent: Page/Page column 16 ;
反应条件
1: With lithium tert-butylate in methyl t-butyl ether (MTBE) T=20 - 25°C; 16 h; 2: With hydrogenchloride in methyl t-butyl ether (MTBE); water Product distribution / selectivity;
参考文献
MERCK and CO., INC.
Patent: EP968197 B1, 2005 ;
Location in patent: Page/Page column 16 ;