4-(4-氯苯氧基)苯甲酸合成路线 (共 12 条)
反应条件
water; sodium hydroxide in methanol T=0 - 60°C; 3 h;
参考文献
PFIZER INC.; SPRINGER, John Robert; DEVADAS, Balekudru; GARLAND, Danny James; GRAPPERHAUS, Margaret Lanahan; HAN, Seungil; HOCKERMAN, Susan Landis; HUGHES, Robert Owen; SAIAH, Eddine; SCHNUTE, Mark Edward; SELNESS, Shaun Raj; WALKER, Daniel Patrick; WAN, Zhao-Kui; XING, Li; ZAPF, Christoph Wolfgang; SCHMIDT, Michelle, Ann
Patent: WO2014/68527 A1, 2014 ;
Location in patent: Page/Page column 91 ;
反应条件
dihydrogen peroxide; potassium hydroxide in methanol; ethanol 4 h; Reflux;
参考文献
Rodrigues, Tiago; Ressurreicao, Ana S.; Da Cruz, Filipa P.; Albuquerque, Ines S.; Gut, Jiri; Carrasco, Marta P.; Goncalves, Daniel; Guedes, Rita C.; Dos Santos, Daniel J.V.A.; Mota, Maria M.; Rosenthal, Philip J.; Moreira, Rui; Prudencio, Miguel; Lopes, Francisca
European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 872 - 880
反应条件
sodium hydrogensulfite in ethanol; water
参考文献
Syntex (U.S.A.) Inc.
Patent: US5034410 A1, 1991 ;
反应条件
hydrogenchloride; sodium hypochlorite in ethanol; water
参考文献
Haydock; Mulholland; Telford; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 3 p. 205 - 214
反应条件
1: sodium carbonate / N,N-dimethyl-formamide / 24 h / |Reflux 2: potassium hydroxide; dihydrogen peroxide / methanol; ethanol / 4 h / |Reflux View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 69, p. 872 - 880
反应条件
1: sodium carbonate / N,N-dimethyl-formamide / 24 h / |Reflux 2: potassium hydroxide; dihydrogen peroxide / methanol; ethanol / 4 h / |Reflux View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 69, p. 872 - 880
反应条件
1: 4-(N,N-dimethlyamino)pyridine; copper diacetate / dichloromethane / 48 h / 20 °C / |Molecular sieve 2: water; sodium hydroxide / methanol / 3 h / 0 - 60 °C View Scheme
反应条件
1: 4-(N,N-dimethlyamino)pyridine; copper diacetate / dichloromethane / 48 h / 20 °C / |Molecular sieve 2: water; sodium hydroxide / methanol / 3 h / 0 - 60 °C View Scheme
反应条件
potassium permanganate
参考文献
Pr. Irish Acad., , vol. 53 B, p. 61,70
反应条件
1: ueber die Diazonium-Verbindung dargestellt 2: aq. NaOH solution View Scheme