4-4-(2-甲氧基-苯基)-哌嗪-1-基-丁基胺合成路线 (共 7 条)
反应条件
hydrazine hydrate in methanol 2 h; Heating;
参考文献
Hackling, Anneke; Ghosh, Robin; Perachon, Sylvie; Mann, Andre; Hoeltje, Hans-Dieter; Wermuth, Camille G.; Schwartz, Jean-Charles; Sippl, Wolfgang; Sokoloff, Pierre; Stark, Holger
Journal of Medicinal Chemistry, 2003 , vol. 46, # 18 p. 3883 - 3899
反应条件
lithium aluminium tetrahydride in diethyl ether T=0 - 20°C;
参考文献
Skultety, Marika; Huebner, Harald; Loeber, Stefan; Gmeiner, Peter
Journal of Medicinal Chemistry, 2010 , vol. 53, # 19 p. 7219 - 7228
反应条件
potassium carbonate in N-methyl-acetamide; hydrazine hydrate
参考文献
Neurogen Corporation
Patent: US5703237 A1, 1997 ;
US 5703237 A
反应条件
1: 75 percent / K2CO3 / acetonitrile / 14 h / Heating 2: 93 percent / hydrazine hydrate / methanol / 2 h / Heating View Scheme
参考文献
Hackling, Anneke; Ghosh, Robin; Perachon, Sylvie; Mann, Andre; Hoeltje, Hans-Dieter; Wermuth, Camille G.; Schwartz, Jean-Charles; Sippl, Wolfgang; Sokoloff, Pierre; Stark, Holger
Journal of Medicinal Chemistry, 2003 , vol. 46, # 18 p. 3883 - 3899
反应条件
1.1: K2CO3 / acetonitrile / 12 h / Heating 2.1: hydrazine hydrate / methanol / 2 h / Heating 2.2: 92 percent / HCl / methanol / 1 h / Heating View Scheme
参考文献
Chu, Wenhua; Tu, Zhude; McElveen, Elizabeth; Xu, Jinbin; Taylor, Michelle; Luedtke, Robert R.; MacH, Robert H.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 1 p. 77 - 87
反应条件
in diethyl ether Product distribution / selectivity;
参考文献
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Patent: EP1683790 A1, 2006 ;
Location in patent: Page/Page column 11 ;
EP 1683790 A1
反应条件
triethylamine in toluene
参考文献
Roussel-UCLAF
Patent: US3966950 A1, 1976 ;