N-甲基-N-硫代苯甲酰肼合成路线 （共 15 条）
反应条件
triethylamine in ethyl acetate T=0 - 10°C; 0.5 h;
参考文献
Journal of Inorganic Biochemistry, , vol. 126, p. 1 - 6
反应条件
N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide in N,N-dimethyl-formamide T=17 - 25°C; 2 h; Cooling with water-ice; Product distribution / selectivity;
参考文献
WO2009/73147 A2, ;
Page/Page column 36-37 ;
反应条件
1: 76 percent / acetonitrile / 16 h / Ambient temperature 2: ethanol / 24 h / Ambient temperature 3: conc. aq. HCl / 0.5 h / Ambient temperature 4: 79 percent / methanol / 2 h / Ambient temperature View Scheme
参考文献
Neunhoeffer, Hans; Karafiat, Ute; Koehler, Gernot; Sowa, Birgit
Liebigs Annalen der Chemie, 1992 , # 2 p. 115 - 126
反应条件
1: With sodium hydroxide in water
T=0 - 10°C;
2: in water
T=0 - 5°C; 0.5 h;
参考文献
Yadav, Arun A.; Patel, Daywin; Wu, Xing; Hasinoff, Brian B.
Journal of Inorganic Biochemistry, 2013 , vol. 126, p. 1 - 6
参考文献
Jensen,K.A. et al.
Acta Chemica Scandinavica (1947-1973), 1961 , vol. 15, p. 1109 - 1123
反应条件
carbon disulfide in tetrahydrofuran; water; ethyl acetate
参考文献
Synta Pharmaceuticals Corp.
Patent: US6924312 B2, 2005 ;
反应条件
sodium hydroxide in water
T=0 - 10°C; 0.5 h;
参考文献
SYNTA PHARMACEUTICALS CORP.
Patent: WO2009/73147 A2, 2009 ;
Location in patent: Page/Page column 34-35 ;
反应条件
2: hydrogen sulfide / ethanol
3: sodium hydroxide
View Scheme
参考文献
Chen, Shoujun; Sun, Lijun; Koya, Keizo; Tatsuta, Noriaki; Xia, Zhiqiang; Korbut, Timothy; Du, Zhenjian; Wu, Jim; Liang, Guiqing; Jiang, Jun; Ono, Mitsunori; Zhou, Dan; Sonderfan, Andrew
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 18 p. 5070 - 5076
反应条件
1.1: diethyl ether
2.2: |Acidic conditions
3.1: sodium hydroxide
View Scheme
参考文献
Chen, Shoujun; Sun, Lijun; Koya, Keizo; Tatsuta, Noriaki; Xia, Zhiqiang; Korbut, Timothy; Du, Zhenjian; Wu, Jim; Liang, Guiqing; Jiang, Jun; Ono, Mitsunori; Zhou, Dan; Sonderfan, Andrew
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 18 p. 5070 - 5076
反应条件
1: dichloromethane
2: P2S2 / benzene-d6 / |Reflux
View Scheme
参考文献
Chen, Shoujun; Sun, Lijun; Koya, Keizo; Tatsuta, Noriaki; Xia, Zhiqiang; Korbut, Timothy; Du, Zhenjian; Wu, Jim; Liang, Guiqing; Jiang, Jun; Ono, Mitsunori; Zhou, Dan; Sonderfan, Andrew
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 18 p. 5070 - 5076
