2-(氯甲基)苯并[b]噻吩合成路线 （共 15 条）
反应条件
thionyl chloride in toluene T=50°C; 2 h;
参考文献
Larsen, Jan; Bechgaard, Klaus
Acta Chemica Scandinavica, 1996 , vol. 50, # 1 p. 71 - 76
反应条件
1.1: n-BuLi / tetrahydrofuran; heptane / 1 h / -78 °C 1.2: 62 percent / tetrahydrofuran; heptane / 2 h / -78 - -10 °C 2.1: NaBH4 / methanol / 20 °C 3.1: SOCl2; benzotriazole / CH2Cl2 View Scheme
参考文献
Blicke; Sheets
Journal of the American Chemical Society, 1949 , vol. 71, p. 2856,2858
反应条件
1: NaBH4 / methanol / 20 °C 2: SOCl2; benzotriazole / CH2Cl2 View Scheme
参考文献
Larsen, Jan; Bechgaard, Klaus
Acta Chemica Scandinavica, 1996 , vol. 50, # 1 p. 71 - 76
反应条件
1: lithium tri-tert-butoxyaluminohydride / tetrahydrofuran 2: methanesulfonyl chloride, pyridine View Scheme
参考文献
Mylari; Beyer; Scott; Aldinger; Dee; Siegel; Zembrowski
Journal of Medicinal Chemistry, 1992 , vol. 35, # 3 p. 457 - 465
反应条件
1: lithium alanate; diethyl ether 2: thionyl chloride View Scheme
参考文献
Blicke; Sheets
Journal of the American Chemical Society, 1949 , vol. 71, p. 2856,2858
反应条件
in acetonitrile 20 h; Heating;
参考文献
Saari, Walfred S.; Wai, John S.; Fisher, Thorsten E.; Thomas, Craig M.; Hoffman, Jacob M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 21 p. 3792 - 3802
反应条件
1: 94 percent / ethanol / 3 h / Heating 2: 1.) sodium hydride, 2.) acetophenone / 1.) THF, DMSO, 0 deg C, 20 min, 2.) 0 deg C, 14 h. View Scheme
参考文献
Tominaga, Yoshinori; Pratap, Ram; Castle, Raymond N.; Lee, Milton L.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 871 - 877
参考文献
Blicke; Sheets
Journal of the American Chemical Society, 1949 , vol. 71, p. 2856,2858
反应条件
thionyl chloride in water; ethyl acetate; Petroleum ether
参考文献
Knoll Aktiengesellschaft
Patent: US6187802 B1, 2001 ;
参考文献
Blicke; Sheets
Journal of the American Chemical Society, 1949 , vol. 71, p. 2856,2858
