1-甲基-4-羟基-哌啶-4-甲腈合成路线 （共 8 条）
反应条件
hydrogenchloride in water
参考文献
Israel Institute for Biological Research
Patent: US5852029 A1, 1998 ;
US 5852029 A
反应条件
ammonium chloride in methanol; ethanol; water
参考文献
Israel Institute for Biological Research
Patent: US5852029 A1, 1998 ;
US 5852029 A
反应条件
ammonium chloride in methanol; ethanol; water
参考文献
Fisher; Abraham; Karton; Yishai; Marciano; Daniele; Barak; Dov; Meshulam; Haim
Patent: US5534520 A1, 1996 ;
参考文献
Abbott Laboratories
Patent: US3931198 A1, 1976 ;
反应条件
in methanol; water Ambient temperature;
参考文献
Iorio; Molinari; Scotti de Carolis; Niglio
Farmaco, Edizione Scientifica, 1984 , vol. 39, # 7 p. 599 - 611
参考文献
Lyle; Lyle
Journal of the American Chemical Society, 1954 , vol. 76, p. 3536,3538
反应条件
in water T=0°C; 3 h;
参考文献
Swain; Baker; Kneen; Herbert; Moseley; Saunders; Seward; Stevenson; Beer; Stanton; Watling; Ball
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1019 - 1031
反应条件
1: concentrated aqueous HCl. / Erwaermen des Reaktionsprodukts mit aethanol. H2SO4
2: diethyl ether
3: concentrated sulfuric acid / 0 °C
View Scheme
参考文献
Lyle; Lyle
Journal of the American Chemical Society, 1954 , vol. 76, p. 3536,3538
