I2; CuI in tetrahydrofuran

copper(l) iodide; diiodomethane in tetrahydrofuran Heating;

1: 6-chloro-2-iodo-(9H)-purine With di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran T=-50°C; 0.166667 h; 2: isopropyl alcohol in tetrahydrofuran T=20°C; 48 h;

triphenylphosphine in tetrahydrofuran T=-30°C; Title compound not separated from byproducts.;

1: 98 percent / CuCl2 / aq. ethanol / 5 h / 85 °C 2: Ph3P / tetrahydrofuran / -30 °C View Scheme

1.1: 86 percent / POCl3 / N,N-dimethyl-acetamide / 2 h / 120 °C 2.1: 68 percent / p-TsOH / tetrahydrofuran / 80 °C 3.1: n-BuLi; 2,2,6,6-tetramethylpiperidine / hexane; tetrahydrofuran / 0.5 h / -78 °C 3.2: Bu3SnCl / hexane; tetrahydrofuran / 1 h / -78 °C 3.3: 8.0 g / iodine / tetrahydrofuran / 24 h 4.1: 98 percent / CuCl2 / aq. ethanol / 5 h / 85 °C 5.1: Ph3P / tetrahydrofuran / -30 °C View Scheme

1.1: 68 percent / p-TsOH / tetrahydrofuran / 80 °C 2.1: n-BuLi; 2,2,6,6-tetramethylpiperidine / hexane; tetrahydrofuran / 0.5 h / -78 °C 2.2: Bu3SnCl / hexane; tetrahydrofuran / 1 h / -78 °C 2.3: 8.0 g / iodine / tetrahydrofuran / 24 h 3.1: 98 percent / CuCl2 / aq. ethanol / 5 h / 85 °C 4.1: Ph3P / tetrahydrofuran / -30 °C View Scheme

1.1: n-BuLi; 2,2,6,6-tetramethylpiperidine / hexane; tetrahydrofuran / 0.5 h / -78 °C 1.2: Bu3SnCl / hexane; tetrahydrofuran / 1 h / -78 °C 1.3: 8.0 g / iodine / tetrahydrofuran / 24 h 2.1: 98 percent / CuCl2 / aq. ethanol / 5 h / 85 °C 3.1: Ph3P / tetrahydrofuran / -30 °C View Scheme

1: conc. HCl / N,N-dimethyl-acetamide / Ambient temperature 2: 82 percent / CH2I2, CuI / tetrahydrofuran / Heating View Scheme

triethylamine in ethanol T=60°C; 48 h;