1-(3-氯丙基)-4-甲基哌嗪二盐酸盐合成路线 （共 6 条）
反应条件
1: With sodium hydroxide in water; acetone T=0 - 20°C; 24 h; 2: With hydrogenchloride in ethanol
参考文献
JOHANNES GUTENBERG-UNIVERSITAeT MAINZ; DANNHARDT, Gerd; KRAMB, Jan-Peter; PLUTIZKI, Stanislav
Patent: WO2011/73092 A1, 2011 ;
Location in patent: Page/Page column 29; 30 ;
WO 2011/073092 A1
参考文献
Monatshefte fuer Chemie, , vol. 87, p. 701,706
反应条件
sodium hydroxide in toluene 15 h; Heating;
参考文献
Grisenko,A.N.; Zhuravlev,S.V.
J. Gen. Chem. USSR (Engl. Transl.), 1962 , vol. 32, p. 1915 - 1919,1892 - 1895
反应条件
sodium hydroxide in toluene 14 h; Heating;
参考文献
Grisenko,A.N.; Zhuravlev,S.V.
J. Gen. Chem. USSR (Engl. Transl.), 1962 , vol. 32, p. 1915 - 1919,1892 - 1895
反应条件
sodium hydroxide in toluene 15 h; Heating;
参考文献
Grisenko,A.N.; Zhuravlev,S.V.
J. Gen. Chem. USSR (Engl. Transl.), 1962 , vol. 32, p. 1915 - 1919,1892 - 1895
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=80°C; 4 h;
参考文献
Malecki, Natacha; Carato, Pascal; Rigo, Benoit; Goossens, Jean-Francois; Houssin, Raymond; Bailly, Christian; Henichart, Jean-Pierre
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 3 p. 641 - 647
