2-甲氧基-3-硝基吡啶合成路线 （共 14 条）
反应条件
in methanol T=0°C; 4 h;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; CLEVELAND, Thomas; MAKINGS, Lewis R.; HAMILTON, Matthew; GROOTENHUIS, Peter D.J.
Patent: WO2005/26137 A2, 2005 ;
Location in patent: Page/Page column 233 ;
WO 2005/026137 A2
反应条件
sodium methylate in methanol
参考文献
C.D. Searle and Co.
Patent: US5652363 A1, 1997 ;
反应条件
1: methanol With sodium hydride in tetrahydrofuran; mineral oil 0.166667 h; Inert atmosphere; 2: 2-chloro-3-nitro-pyridine in tetrahydrofuran; mineral oil T=-20 - 0°C; 1.33333 h; Inert atmosphere;
参考文献
Jeanty, Matthieu; Blu, Jerome; Suzenet, Franck; Guillaumet, Gerald
Organic Letters, 2009 , vol. 11, # 22 p. 5142 - 5145
反应条件
1: phosphoryl chloride; phosphorus (V)-chloride 2: methanol View Scheme
参考文献
Journal of the Chemical Society, , p. 4516,4520
参考文献
Canadian Journal of Chemistry, , vol. 31, p. 1181,1183,1186
反应条件
N,N-dimethyl-formamide; trichlorophosphate T=90°C; 10 h;
参考文献
Lai, Long-Li; Lin, Pen-Yuan; Wang, Jy-Shih; Hwu, Jih Ru; Shiao, Min-Jen; Tsay, Shwu-Chen
Journal of Chemical Research - Part S, 1996 , # 4 p. 194 - 195
反应条件
ammonium acetate in water
参考文献
Eli Lilly and Company
Patent: US4552967 A1, 1985 ;
反应条件
1: hydrogen / palladium 10 on activated carbon / methanol / 4 h 2: N-bromosuccinmide / N,N-dimethyl-formamide / -30 °C View Scheme
参考文献
TAISHO PHARMACEUTICAL CO., LTD; NISSAN CHEMICAL INDUSTRIES, LTD.
Patent: US2011/237791 A1, 2011 ;
反应条件
1: 99 percent / hydrogen / palladized charcoal / methanol; tetrahydrofuran / 1 h / 20 °C 2: NEt3 / CH2Cl2 / 0 - 20 °C View Scheme
参考文献
Dolle, Valerie; Nguyen, Chi Hung; Bisagni, Emile
Tetrahedron, 1997 , vol. 53, # 37 p. 12505 - 12524
反应条件
in tetrahydrofuran T=-78 - -20°C; 8 h;
参考文献
Zhang, Zhongxing; Yang, Zhong; Meanwell, Nicholas A.; Kadow, John F.; Wang, Tao
Journal of Organic Chemistry, 2002 , vol. 67, # 7 p. 2345 - 2347
