3-氧代-3,4-二氢-2H-1,4-苯并噁嗪-6-甲酸甲酯合成路线 (共 23 条)
反应条件
N-benzyl-N,N,N-triethylammonium chloride; sodium hydrogencarbonate in chloroform T=55°C; 16 h;
参考文献
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.
Patent: WO2004/7491 A1, 2004 ;
Location in patent: Page 76 ;
反应条件
1: With potassium carbonate in acetone T=55°C; 18 h; 2: With iron; acetic acid T=117°C; 5.5 h;
参考文献
Allison, Brett D.; Gomez, Laurent; Grice, Cheryl A.; Hack, Michael D.; Morrow, Brian J.; Motley, S. Timothy; Santillan, Alejandro; Shaw, Karen J.; Schwarz, Kimberly L.; Tang, Liu Y.; Venkatesan, Hariharan; Wiener, John J. M.
Patent: US2006/223810 A1, 2006 ;
Location in patent: Page/Page column 27 ;
反应条件
hydrogen; 5 palladium over charcoal in tetrahydrofuran; methanol T=20°C;
参考文献
US2006/35939 A1, ;
Page/Page column 25 ;
反应条件
hydrogenchloride; methanol; iron
参考文献
Journal of the American Chemical Society, , vol. 48, p. 464
反应条件
chloro-trimethyl-silane Heating / reflux;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/134378 A1, 2006 ;
Location in patent: Page/Page column 99-100 ;
WO 2006/134378 A1
反应条件
sodium hydrogencarbonate in ethyl acetate 0.5 h; Ambient temperature;
参考文献
Yamamoto, Takeshi; Hori, Manabu; Watanabe, Ikuo; Tsutsui, Hisayoshi; Harada, Kengo; Ikeda, Shqji; Maruo, Joji; Morita, Tominori; Ohtaka, Hiroshi
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 11 p. 1716 - 1723
反应条件
1: 77 percent / sodium hydrocarbonate / acetone / 16 h / Heating 2: hydrogen / Pd/C / methanol; tetrahydrofuran / 16 h / 20 °C 3: 700 mg / acetic acid / methanol; tetrahydrofuran / 0.5 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 24 p. 8219 - 8248
反应条件
1: 93 percent / sulfuric acid / 16 h / Heating 2: 77 percent / sodium hydrocarbonate / acetone / 16 h / Heating 3: hydrogen / Pd/C / methanol; tetrahydrofuran / 16 h / 20 °C 4: 700 mg / acetic acid / methanol; tetrahydrofuran / 0.5 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 24 p. 8219 - 8248
反应条件
1: hydrochloric acid 2: HNO3+H2SO4 3: iron powder; concentrated hydrochloric acid; methanol View Scheme
参考文献
Journal of the American Chemical Society, , vol. 48, p. 464
反应条件
1: HNO3+H2SO4 2: iron powder; concentrated hydrochloric acid; methanol View Scheme
参考文献
Journal of the American Chemical Society, , vol. 48, p. 464