2-氯-n-(3,4-二氯苯基)乙酰胺合成路线 (共 5 条)
反应条件
triethylamine in dichloromethane T=0 - 20°C;
参考文献
Mosley, Cara A.; Myers, Scott J.; Murray, Ernest E.; Santangelo, Rose; Tahirovic, Yesim A.; Kurtkaya, Natalie; Mullasseril, Praseeda; Yuan, Hongjie; Lyuboslavsky, Polina; Le, Phuong; Wilson, Lawrence J.; Yepes, Manuel; Dingledine, Ray; Traynelis, Stephen F.; Liotta, Dennis C.
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 17 p. 6463 - 6480
反应条件
potassium carbonate in water; acetone
参考文献
Laboratoire L. Lafon
Patent: US4325964 A1, 1982 ;
反应条件
sodium chloride; sodium hydrogencarbonate; chloroacetic acid in tetrahydrofuran; hexane; di-isopropyl ether; ethyl acetate
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6562978 B1, 2003 ;
反应条件
in tetrahydrofuran T=20°C; 3 h;
参考文献
Imamura, Shinichi; Nishikawa, Youichi; Ichikawa, Takashi; Hattori, Taeko; Matsushita, Yoshihiro; Hashiguchi, Shohei; Kanzaki, Naoyuki; Iizawa, Yuji; Baba, Masanori; Sugihara, Yoshihiro
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 2 p. 397 - 416
反应条件
thionyl chloride in methanol 1 h; Reflux;
参考文献
Wang, Gong-Bao; Wang, Lin-Fa; Li, Chao-Zhang; Sun, Jing; Zhou, Guang-Ming; Yang, Da-Cheng
Research on Chemical Intermediates, 2012 , vol. 38, # 1 p. 77 - 89