2-氨基-4-苯基噻唑合成路线 （共 144 条）
反应条件
sodium hydrogen sulphate in water T=20°C; Hantzsch reaction; 0.416667 h; regioselective reaction;
参考文献
Rostamizadeh, Shahnaz; Aryan, Reza; Ghaieni, Hamid R.; Amani, Ali M.
Monatshefte fur Chemie, 2008 , vol. 139, # 10 p. 1241 - 1245
反应条件
1: With ammonium acetate; acetic acid in toluene T=100°C; 6 h; 2: With sodium hydroxide in dichloromethane; water
参考文献
PROSKELIA SAS
Patent: WO2006/117211 A2, 2006 ;
Location in patent: Page/Page column 47-48 ;
WO 2006/117211 A2
反应条件
iodine T=80 - 90°C; 4 h;
参考文献
Parekh, Nikhil M.; Juddhawala, Krunal V.; Rawal, Bhaskar M.
Medicinal Chemistry Research, 2013 , vol. 22, # 6 p. 2737 - 2745
反应条件
sodium carbonate in poly(ethylene glycol-400) T=20°C; 1 h;
参考文献
Lin, Pei-Ying; Hou, Rei-Sheu; Wang, Huey-Min; Kang, Iou-Jiun; Chen, Ling-Ching
Journal of the Chinese Chemical Society, 2009 , vol. 56, # 3 p. 455 - 458
反应条件
sulfuryl dichloride; ammonia; thiourea in water
参考文献
Pierre Fabre, S.A.
Patent: US4225610 A1, 1980 ;
参考文献
Microcide Pharmaceuticals, Inc.; DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1227084 A1, 2002 ;
反应条件
in dichloromethane; N,N-dimethyl-formamide T=25°C; 12 h; regioselective reaction;
参考文献
Donohoe, Timothy J.; Kabeshov, Mikhail A.; Rathi, Akshat H.; Smith, Ian E. D.
Synlett, 2010 , # 19 p. 2956 - 2958
反应条件
in isopropyl alcohol T=25°C; 3 h;
参考文献
FUJIFILM Corporation
Patent: EP1975204 A2, 2008 ;
Location in patent: Page/Page column 16 ;
反应条件
copper(II) bis(trifluoromethanesulfonate) in 1,2-dichloro-ethane T=80°C; 2 h;
参考文献
Yadav; Reddy, B.V. Subba; Rao, Y. Gopala; Narsaiah
Tetrahedron Letters, 2008 , vol. 49, # 15 p. 2381 - 2383
反应条件
in ethanol T=140°C; 0.1 h; Microwave irradiation; TemperatureTime;
参考文献
Bowman, Matthew D.; Holcomb, Jennifer L.; Kormos, Chad M.; Leadbeater, Nicholas E.; Williams, Victoria A.
Organic Process Research and Development, 2008 , vol. 12, # 1 p. 41 - 57
