4-[2-(二甲基氨基)乙氧基]苄胺合成路线 （共 18 条）
反应条件
1: With hydroxylamine hydrochloride in water; acetic acid T=0 - 5°C; 2 h; 2: With acetic acid; zinc in water T=45 - 70°C; 7 h;
参考文献
WO2006/51079 A1, ;
Page/Page column 5-6 ;
反应条件
ammonia; hydrogen; Raney Ni in toluene T=80°C; P=48754.9 Torr; 1.33333 h; Product distribution / selectivity;
参考文献
WO2004/13082 A2, ;
Page/Page column 10 ;
反应条件
1: 2-(dimethylamino)-ethanol With sodium hydride T=130 - 140°C; 1 h; 2: 4-fluoro-benzylamine T=130 - 140°C; 5 h; Product distribution / selectivity;
参考文献
WO2006/11696 A1, ;
Page/Page column 7-8 ;
反应条件
1: sodium methylate; chlorobenzene 2: Raney nickel; ethanol; NH3 / 80 °C / 51485.6 Torr / Hydrogenation View Scheme
反应条件
1: potassium carbonate / ethyl acetate / 2.5 h / 10 °C / |Inert atmosphere; |Large scale 2: hydrogenchloride / acetone; water / |Large scale View Scheme
参考文献
Neelakandan; Manikandan; Santosha; Prabhakaran
Organic Process Research and Development, 2013 , vol. 17, # 7 p. 981 - 984
反应条件
potassium carbonate in ethyl acetate T=10°C; 2.5 h; Inert atmosphereLarge scale; Concentration;
参考文献
Organic Process Research and Development, , vol. 17, # 7 p. 981 - 984
反应条件
thionyl chloride; N,N-dimethyl-formamide Reagent/catalyst;
参考文献
Organic Process Research and Development, , vol. 17, # 7 p. 981 - 984
反应条件
triethylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) in 1,4-dioxane T=80°C; Inert atmosphereSealed chamber;
参考文献
Hermange, Philippe; Lindhardt, Anders T.; Taaning, Rolf H.; Bjerglund, Klaus; Lupp, Daniel; Skrydstrup, Troels
Journal of the American Chemical Society, 2011 , vol. 133, # 15 p. 6061 - 6071
反应条件
triethylamine in chloroform 2 h; Ambient temperature; Yield given;
参考文献
Sakaguchi; Nishino; Ogawa; Iwanaga; Yasuda; Kato; Ito
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 1 p. 202 - 211
