3-(2-硝基苯基)丙酸合成路线 （共 24 条）
反应条件
1: With hydrogenchloride; acetic acid in water 48 h; Reflux; 2: With sodium hydroxide in water
参考文献
GRUeNENTHAL GMBH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; SCHIENE, Klaus; DE VRY, Jean; DAMANN, Nils; FRORMANN, Sven; LESCH, Bernhard; LEE, Jeewoo; KIM, Yong-Soo; KIM, Myeong-Seop
Patent: WO2010/127855 A1, 2010 ;
Location in patent: Page/Page column 145; 146 ;
反应条件
sulfuric acid T=130 - 135°C; 4.5 h;
参考文献
Liu, Bin; Hu, Longqin
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 3889 - 3899
参考文献
Chemische Berichte, , vol. 12, p. 600
Zeitschrift fuer Chemie, , p. 193
Justus Liebigs Annalen der Chemie, , vol. 163, p. 126
反应条件
nitric acid in dichloromethane 24 h; Ambient temperature;
参考文献
Journal of Organic Chemistry, , vol. 63, # 4 p. 952 - 958
反应条件
1: 90 percent / BH3 / tetrahydrofuran / 20 h / 20 °C 2: 82 percent / pyridine / 3 h / 20 °C 3: 86 percent / 1-methyl-pyrrolidin-2-one / 1 h / 90 - 100 °C 4: 100 percent / aqueous sulfuric acid / 4.5 h / 130 - 135 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 11, # 18 p. 3889 - 3899
反应条件
1: 82 percent / pyridine / 3 h / 20 °C 2: 86 percent / 1-methyl-pyrrolidin-2-one / 1 h / 90 - 100 °C 3: 100 percent / aqueous sulfuric acid / 4.5 h / 130 - 135 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 11, # 18 p. 3889 - 3899
反应条件
1: 86 percent / 1-methyl-pyrrolidin-2-one / 1 h / 90 - 100 °C 2: 100 percent / aqueous sulfuric acid / 4.5 h / 130 - 135 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 11, # 18 p. 3889 - 3899
反应条件
ethanol Erhitzen des Reaktionsprodukts mit wss. H2SO4;
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 23, p. 1902,1907
反应条件
(i) Mg, EtOH, CCl4, (ii) /BRN= 388396/, (iii) aq. HCl, AcOH; Multistep reaction;
参考文献
Helvetica Chimica Acta, , vol. 44, p. 1736 - 1747
反应条件
Acidic conditionsHeating;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 6 p. 1693 - 1698
