1-乙酰氨基-3,5-二甲基金刚烷合成路线 （共 15 条）
反应条件
1: With sulfuric acid in acetic acid T=20 - 75°C; Ritter Reaction; 4 h; 2: With water in acetic acid; toluene T=5 - 25°C; 0.75 h;
参考文献
A.M.S.A. ANONIMA MATERIE SINTETICHE E AFFINI S.p.A.
Patent: EP1721888 A1, 2006 ;
Location in patent: Page/Page column 7; 13 ;
参考文献
Ren, Huixue; Ying, Hanjie; Ouyang, Pingkai; Lin, Jimao; Jing, Liu
Asian Journal of Chemistry, 2012 , vol. 24, # 11 p. 5107 - 5110
反应条件
1: 1,3-dimethyladamantane With sulfuric acid; nitric acid T=0°C; 6 h; 2: acetonitrile T=0 - 20°C; Ritter-type reaction; 3.5 h; Further stages.;
参考文献
Wanka, Lukas; Cabrelle, Chiara; Vanejews, Maksims; Schreiner, Peter R.
European Journal of Organic Chemistry, 2007 , # 9 p. 1474 - 1490
反应条件
trifluoroacetic acid T=90 - 100°C; 10 h;
参考文献
Plakhotnik, V.M.; Kovtun, V.Yu.; Yashunskii, V.G.
Journal of Organic Chemistry USSR (English Translation), 1982 , vol. 18, p. 867 - 871
Zhurnal Organicheskoi Khimii, 1982 , vol. 18, # 5 p. 1001 - 1005
反应条件
nitric acid T=120°C; 2 h;
参考文献
Klimochkin, Yu. N.; Bagrii, E. I.; Dolgopolova, T. N.; Moiseev, I. K.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1988 , vol. 37, p. 757 - 759
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1988 , # 4 p. 878 - 880
参考文献
Moiseev, I. K.; Bagrii, E. I.; Klimochkin, Yu. N.; Dolgopolova, T. N.; Zemtsova, M. N.; Trakhtenberg, P. L.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1985 , vol. 34, p. 1983 - 1985
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1985 , # 9 p. 2144 - 2146
反应条件
T=25 - 140°C; 3 - 5 h; Product distribution / selectivity;
参考文献
WO2008/62472 A2, ;
Page/Page column 13-17 ;
反应条件
1: bromine / 12 h / Reflux 2: sulfuric acid / 12 h View Scheme
参考文献
Asian Journal of Chemistry, , vol. 24, # 11 p. 5107 - 5110
反应条件
1: With sodium hydroxide in diethylene glycol 6 h; Reflux; 2: With water in dichloromethane; diethylene glycol T=20°C; 0.25 h; 3: With hydrogenchloride in ethyl acetate T=0 - 30°C; 6 h;
参考文献
HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; RAJI REDDY, Rapolu; RAMAKRISHNA REDDY, Matta; VAMSI KRISHNA, Bandi
Patent: WO2011/125062 A1, 2011 ;
Location in patent: Page/Page column 8-9 ;
反应条件
1: With sodium hydroxide in diethylene glycol T=105 - 170°C; 10 h; 2: With hydrogenchloride in water; toluene T=5 - 15°C; 2.5 h; Product distribution / selectivity;
参考文献
CADILA HEALTHCARE LIMITED
Patent: WO2008/62472 A2, 2008 ;
Location in patent: Page/Page column 16-17 ;
