5-(三氟甲基)异吲哚啉-1,3-二酮合成路线 （共 6 条）
参考文献
Pawlowski, Georg; Hanack, Michael
Synthetic Communications, 1981 , vol. 11, # 5 p. 351 - 364
反应条件
1: 92 percent / acetic anhydride / 2 h / Heating 2: 91 percent / urea / 2 h / 170 °C View Scheme
参考文献
Pawlowski, Georg; Hanack, Michael
Synthetic Communications, 1981 , vol. 11, # 5 p. 351 - 364
反应条件
1: 82 percent / CrO3, H2SO4 conc. / acetic acid / 4 h / 15 - 40 °C 2: 92 percent / acetic anhydride / 2 h / Heating 3: 91 percent / urea / 2 h / 170 °C View Scheme
参考文献
Pawlowski, Georg; Hanack, Michael
Synthetic Communications, 1981 , vol. 11, # 5 p. 351 - 364
反应条件
hydrogenchloride; iron(III) chloride 1.) DMF, reflux, 1 h, 2.) DMF,65 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Watanabe, Nobuhisa; Kabasawa, Yasuhiro; Takase, Yasutaka; Matsukura, Masayuki; Miyazaki, Kazuki; Ishihara, Hiroki; Kodama, Kohtarou; Adachi, Hideyuki
Journal of Medicinal Chemistry, 1998 , vol. 41, # 18 p. 3367 - 3372
反应条件
borane in tetrahydrofuran
参考文献
Van Goethem, Sebastiaan; Van der Veken, Pieter; Dubois, Veronique; Soroka, Anna; Lambeir, Anne-Marie; Chen, Xin; Haemers, Achiel; Scharpe, Simon; De Meester, Ingrid; Augustyns, Koen
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 14 p. 4159 - 4162
反应条件
(i) aq. KOH, (ii) aq. HCl; Multistep reaction;
参考文献
Loev,B.
Canadian Journal of Chemistry, 1964 , vol. 42, p. 1488 - 1490
