1-溴-3-甲基-2-丁酮合成路线 （共 56 条）
参考文献
Chen, Li; Dillon, Michael Patrick; Feng, Lichun; Hawley, Ronald Charles; Yang, Minmin
Patent: US2012/22067 A1, 2012 ;
Location in patent: Page/Page column 38 ;
US 20120022067 A1
参考文献
Hebeisen, Paul; Kitas, Eric A.; Minder, Rudolf E.; Mohr, Peter; Wessel, Hans Peter
Patent: US2009/143448 A1, 2009 ;
反应条件
1: acetone / 18 h / Heating 2: NaH / tetrahydrofuran / 0.5 h / 25 °C 3: 80 percent / LDA / tetrahydrofuran / 1.) -40 to -50 deg C, 30 min, 2.) -75 deg C, 14 h 4: 83 percent / H2, pyridine / 10percent Pd/C / ethanol; tetrahydrofuran / 14 h / 2585.7 Torr / Ambient temperature 5: 99 percent / LAH / tetrahydrofuran / 1.) r.t. 2 h, 2.) reflux, overnight 6: 96 percent / CSA / 24 h / Ambient temperature 7: 91 percent / CrO3, pyridine / CH2Cl2 / 48 h / Ambient temperature 8: 72 percent / <(C6H5)3P>3RhCl / benzene / 5 h / Heating View Scheme
参考文献
McMorris, Trevor C.; Chavez, Rodrigo G.; Patil, Prakash A.
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 3 p. 295 - 302
反应条件
1: 86 percent / benzene / 6 h / 60 - 70 °C 2: 96 percent / K2CO3, H2O / acetonitrile / 18 h / 25 °C View Scheme
参考文献
Huang; Shi; Li
Synthesis, 1988 , # 12 p. 975 - 977
反应条件
1.1: 1.5 h / Reflux 1.2: pH 12 2.1: bromine / chloroform / 60 h / 20 °C 3.1: nitric acid; phosphoric acid / 0.08 h 3.2: 0.75 h / -5 °C 3.3: 20.5 h / -5 - 18 °C View Scheme
参考文献
US2012/22067 A1, ;
US 20120022067 A1
反应条件
1.1: 1.5 h / Reflux 1.2: pH 12 2.1: bromine / chloroform / 60 h / 20 °C View Scheme
参考文献
Chen, Li; Dillon, Michael Patrick; Feng, Lichun; Hawley, Ronald Charles; Yang, Minmin
Patent: US2012/22067 A1, 2012 ;
US 20120022067 A1
反应条件
in isobutyramide; water T=20°C; 4 h;
参考文献
FUJIFILM Corporation; ITO, Junichi; YOSHIKAWA, Masaru; MIZUKAWA, Yuki; USHIJIMA, Kenta; KANNA, Shinichi; INABE, Haruki; FUJIE, Yoshihiko; GOTO, Akiyoshi; KANEKO, Yushi; IDEI, Hiroaki
Patent: WO2011/40628 A1, 2011 ;
Location in patent: Page/Page column 302 ;
反应条件
in neat (no solvent) mixt. stirred at 90°C (8 h); chromy.;
参考文献
Huang, Yao-Zeng; Chen, Chen; Shen, Yanchang
Synthetic Communications, 1989 , vol. 19, # 3and4 p. 501 - 510
反应条件
S4N4*SbCl5 in toluene 10 h; Heating;
参考文献
Tetrahedron Letters, , vol. 38, # 24 p. 4227 - 4230
反应条件
palladium dichloride; phosphorous acid trimethyl ester in benzene T=80°C; 5 h;
参考文献
Kosugi, Masanori; Ohya, Takao; Migita, Toshihiko
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 11 p. 3539 - 3540
