4-溴-2-硝基苯乙酸乙酯合成路线 （共 6 条）
反应条件
sulfuric acid 2 h; Heating / reflux;
参考文献
Schumacher, Richard; Danca, Mihaela Diana; Ma, Jianguo; Herbert, Brian; Nguyen, True Minh; Xie, Wenge; Tehim, Ashok
Patent: US2007/78147 A1, 2007 ;
Location in patent: Page/Page column 72 ;
反应条件
hydrogenchloride in ethanol
参考文献
Eli Lilly and Company
Patent: US7034045 B1, 2006 ;
Location in patent: Page/Page column 93 ;
反应条件
sulfuric acid 2 h; Heating / reflux;
参考文献
Xie, Wenge; Herbert, Brian; Ma, Jianguo; Nguyen, Truc Minh; Schumacher, Richard; Gauss, Carla Maria; Tehim, Ashok
Patent: US2005/250808 A1, 2005 ;
Location in patent: Page/Page column 40 ;
US 20050250808 A1
反应条件
1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.67 h / 100 °C 1.2: 1.5 h / 20 - 100 °C 2.1: water; lithium chloride / dimethyl sulfoxide / 3 h / 100 °C View Scheme
参考文献
SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; ZHANG, Jiancun; XIE, Hongming; REN, Qingyun; LI, Shifeng; FU, Changping; HU, Bailin; WU, Xiwei; TANG, Changhua
Patent: WO2014/82380 A1, 2014 ;
参考文献
Zeneca Limited
Patent: US6265411 B1, 2001 ;
反应条件
sodium ethanolate; isopentyl nitrite in ethanol
T=60°C; 2 h;
参考文献
Schumacher, Richard; Danca, Mihaela Diana; Ma, Jianguo; Herbert, Brian; Nguyen, True Minh; Xie, Wenge; Tehim, Ashok
Patent: US2007/78147 A1, 2007 ;
Location in patent: Page/Page column 72 ;
