5-氧代氮杂烷-1,4-二羧酸二乙酯合成路线 （共 8 条）
反应条件
boron trifluoride diethyl etherate in diethyl ether T=-30 - 20°C;
参考文献
Lyles-Eggleston; Altundas; Xia; Sikazwe; Fan; Yang; Li; Zhang; Zhu; Schmidt; Vanase-Frawley; Shrihkande; Villalobos; Borne; Ablordeppey
Journal of Medicinal Chemistry, 2004 , vol. 47, # 3 p. 497 - 508
反应条件
boron trifluoride diethyl etherate in diethyl ether T=-30 - 20°C; 1.5 h;
参考文献
Rawson, Thomas E.; Safina, Brian; Dotson, Jennafer; Zhou, Aihe; Aliagas-Martin, Ignacio; Halladay, Jason; Liang, Jun; Rueth, Matthias; Zhu, Bing-Yan
Patent: US2007/37791 A1, 2007 ;
Location in patent: Page/Page column 54 ;
US 20070037791 A1
反应条件
hydrogenchloride 6 h; Heating;
参考文献
De Ruiter; Andurkar; Riley; Walters; Noggle Jr.
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 4 p. 779 - 786
反应条件
1.1: 84 percent / aq. KOH / ethanol / 24 h / 20 °C 2.1: nBuLi / tetrahydrofuran / 2 h / -78 °C 2.2: 64.3 percent / tetrahydrofuran / -78 - 20 °C 3.1: 73.8 percent / aq. KOH; hydrazine / ethanol / Heating View Scheme
参考文献
Lyles-Eggleston; Altundas; Xia; Sikazwe; Fan; Yang; Li; Zhang; Zhu; Schmidt; Vanase-Frawley; Shrihkande; Villalobos; Borne; Ablordeppey
Journal of Medicinal Chemistry, 2004 , vol. 47, # 3 p. 497 - 508
反应条件
hydrogenchloride 6 h; Heating;
参考文献
Finney, Z. Gail; Riley, Thomas N.
Journal of Medicinal Chemistry, 1980 , vol. 23, # 8 p. 895 - 899
反应条件
1: 4 N HCl / 6 h / Heating
2: 30percent aq. K2CO3 / 4 h / -5 °C
3: ZnCl2 / toluene / 15 h / Heating
4: NaBH4 / methanol / 1 h / Heating
5: 85 percent / 48percent HBr / 3 h / Heating
View Scheme
参考文献
De Ruiter; Andurkar; Riley; Walters; Noggle Jr.
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 4 p. 779 - 786
反应条件
1: TsOH / benzene
2: NH2OH, KOH / methanol
3: aq. HCl / methanol
4: aq. HBr / acetic acid
View Scheme
参考文献
Krogsgaard-Larsen,P.; Hjeds,H.
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1974 , vol. 28, p. 533 - 538
反应条件
potassium hydroxide in ethanol
T=20°C; 24 h;
参考文献
Lyles-Eggleston; Altundas; Xia; Sikazwe; Fan; Yang; Li; Zhang; Zhu; Schmidt; Vanase-Frawley; Shrihkande; Villalobos; Borne; Ablordeppey
Journal of Medicinal Chemistry, 2004 , vol. 47, # 3 p. 497 - 508
